日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO Cells

通过糖基工程化CHO细胞中蛋白质-蛋白质相互作用的鉴定提高HCV E1E2亚单位疫苗候选物的产量

Mina Ying Min Wu ,Frances Rocamora ,Caressa M Robinson ,Seunghyeon Shin ,Svetlana Maurya ,Eric A Toth ,Thomas R Fuerst ,Nathan E Lewis

Glycoengineered recombinant alpha1-antitrypsin results in comparable in vitro and in vivo activities to human plasma-derived protein

糖工程重组 α1-抗胰蛋白酶的体外和体内活性与人类血浆衍生蛋白相当

Frances Rocamora, Sanne Schoffelen, Johnny Arnsdorf, Eric A Toth, Yunus Abdul, Thomas E Cleveland 4th, Sara Petersen Bjørn, Mina Ying Min Wu, Noel G McElvaney, Bjørn Gunnar Rude Voldborg, Thomas R Fuerst, Nathan E Lewis

Site-directed neutralizing antibodies targeting structural sites on SARS-CoV-2 spike protein

针对 SARS-CoV-2 刺突蛋白结构位点的定点中和抗体

Xiaofeng Li, Liudmila Kulakova, Kezzia Jones, Eric A Toth, Marina Kirkland Mitchell, Qiana Mendez, Michael P Weiner, Thomas R Fuerst

Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies

工程化丙型肝炎病毒 E1E2 胞外域与中和抗体的复合物结构

Matthew C Metcalf, Benjamin M Janus, Rui Yin, Ruixue Wang, Johnathan D Guest, Edwin Pozharski, Mansun Law, Roy A Mariuzza, Eric A Toth, Brian G Pierce, Thomas R Fuerst, Gilad Ofek

Engineering subtilisin proteases that specifically degrade active RAS

工程化枯草杆菌蛋白酶,专门降解活性 RAS

Yingwei Chen, Eric A Toth, Biao Ruan, Eun Jung Choi, Richard Simmerman, Yihong Chen, Yanan He, Ruixue Wang, Raquel Godoy-Ruiz, Harlan King, Gregory Custer, D Travis Gallagher, David A Rozak, Melani Solomon, Silvia Muro, David J Weber, John Orban, Thomas R Fuerst, Philip N Bryan

Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer

丙型肝炎病毒 E1E2 异二聚体的天然样分泌形式的设计

Johnathan D Guest, Ruixue Wang, Khadija H Elkholy, Andrezza Chagas, Kinlin L Chao, Thomas E Cleveland 4th, Young Chang Kim, Zhen-Yong Keck, Alexander Marin, Abdul S Yunus, Roy A Mariuzza, Alexander K Andrianov, Eric A Toth, Steven K H Foung, Brian G Pierce, Thomas R Fuerst

Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization

基于结构的丙型肝炎病毒E2糖蛋白设计可提高血清结合率和交叉中和能力

Brian G Pierce # ,Zhen-Yong Keck # ,Ruixue Wang ,Patrick Lau ,Kyle Garagusi ,Khadija Elkholy ,Eric A Toth ,Richard A Urbanowicz ,Johnathan D Guest ,Pragati Agnihotri ,Melissa C Kerzic ,Alexander Marin ,Alexander K Andrianov ,Jonathan K Ball ,Roy A Mariuzza ,Thomas R Fuerst ,Steven K H Foung

Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations

Ca(2+)-S100B 小分子抑制剂揭示两种蛋白质构象

Michael C Cavalier, Mohd Imran Ansari, Adam D Pierce, Paul T Wilder, Laura E McKnight, E Prabhu Raman, David B Neau, Padmavani Bezawada, Milad J Alasady, Thomas H Charpentier, Kristen M Varney, Eric A Toth, Alexander D MacKerell Jr, Andrew Coop, David J Weber

Covalent small molecule inhibitors of Ca(2+)-bound S100B

Ca(2+)结合S100B的共价小分子抑制剂

Michael C Cavalier, Adam D Pierce, Paul T Wilder, Milad J Alasady, Kira G Hartman, David B Neau, Timothy L Foley, Ajit Jadhav, David J Maloney, Anton Simeonov, Eric A Toth, David J Weber

Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast

裂殖酵母中无嘌呤/无嘧啶内切酶 2 (Apn2) 与 Myh1 DNA 糖基化酶的相互作用

Jin Jin, Bor-Jang Hwang, Po-Wen Chang, Eric A Toth, A-Lien Lu