Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells
利用 CRISPR-Cas 介导的精确基因修复技术,最大限度地减少人类造血干细胞中的脱靶突变和非预期靶向突变。
期刊:Science Advances
影响因子:11.7
doi:10.1126/sciadv.abm9106
Ngoc Tung Tran ,Eric Danner ,Xun Li ,Robin Graf ,Mikhail Lebedin ,Kathrin de la Rosa ,Ralf Kühn ,Klaus Rajewsky ,Van Trung Chu