日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants

鉴定出无核苷酸状态是抑制特定致癌 RAS 突变体的治疗弱点

Imran Khan, Akiko Koide, Mariyam Zuberi, Gayatri Ketavarapu, Eric Denbaum, Kai Wen Teng, J Matthew Rhett, Russell Spencer-Smith, G Aaron Hobbs, Ernest Ramsay Camp, Shohei Koide, John P O'Bryan

Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis

靶向 KRAS α4-α5 变构界面可抑制胰腺癌肿瘤发生

Imran Khan, Catherine Marelia-Bennet, Julia Lefler, Mariyam Zuberi, Eric Denbaum, Akiko Koide, Dean M Connor, Ann-Marie Broome, Thierry Pécot, Cynthia Timmers, Michael C Ostrowski, Shohei Koide, John P O'Bryan

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

MLKL 的构象相互转化和与 RIPK3 的脱离先于细胞坏死性凋亡而死亡

Sarah E Garnish #, Yanxiang Meng #, Akiko Koide #, Jarrod J Sandow, Eric Denbaum, Annette V Jacobsen, Wayland Yeung, Andre L Samson, Christopher R Horne, Cheree Fitzgibbon, Samuel N Young, Phoebe P C Smith, Andrew I Webb, Emma J Petrie, Joanne M Hildebrand, Natarajan Kannan, Peter E Czabotar, Shohei

Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies

使用 Monobody 鉴定 MLKL 膜转位作为坏死性细胞死亡的检查点

Emma J Petrie, Richard W Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M Hildebrand, Sarah E Garnish, Katherine A Davies, Jarrod J Sandow, Andre L Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N Young, Patrick J Hennessy, Phoebe P C Smith, Andrew I Webb, Peter E Czabotar, Shohei Koide, James M Mur