日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2)

在神经纤维瘤病 2 型 (NF2) 的转基因小鼠模型中,PAK1 抑制可缩小肿瘤大小并延长小鼠寿命

Eric Hawley, Jeffrey Gehlhausen, Sofiia Karchugina, Hoi-Yee Chow, Daniela Araiza-Olivera, Maria Radu, Abbi Smith, Ciersten Burks, Li Jiang, Xiaohong Li, Waylan Bessler, Andrea Masters, Donna Edwards, Callie Burgin, David Jones, Charles Yates, D Wade Clapp, Jonathan Chernoff, Su-Jung Park

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK

布加替尼通过抑制多种酪氨酸激酶(但不抑制 ALK)导致 NF2 缺陷型脑膜瘤和神经鞘瘤的肿瘤缩小

Long-Sheng Chang, Janet L Oblinger, Abbi E Smith, Marc Ferrer, Steven P Angus, Eric Hawley, Alejandra M Petrilli, Roberta L Beauchamp, Lars Björn Riecken, Serkan Erdin, Ming Poi, Jie Huang, Waylan K Bessler, Xiaohu Zhang, Rajarshi Guha, Craig Thomas, Sarah S Burns, Thomas S K Gilbert, Li Jiang, Xiao

Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling

神经鞘瘤的发生发展是由Hippo通路失调介导的,并受RAS/MAPK信号通路调控。

Zhiguo Chen ,Stephen Li ,Juan Mo ,Eric Hawley ,Yong Wang ,Yongzheng He ,Jean-Philippe Brosseau ,Tracey Shipman ,D Wade Clapp ,Thomas J Carroll ,Lu Q Le

Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 1

小 GTPase RAC1 的基因破坏可防止患有 1 型神经纤维瘤病的小鼠形成丛状神经纤维瘤

Julie A Mund, SuJung Park, Abbi E Smith, Yongzheng He, Li Jiang, Eric Hawley, Michelle J Roberson, Dana K Mitchell, Mohannad Abu-Sultanah, Jin Yuan, Waylan K Bessler, George Sandusky, Shi Chen, Chi Zhang, Steven D Rhodes, D Wade Clapp

A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas

NIK 的蛋白酶体抗性片段介导神经鞘瘤中的致癌 NF-κB 信号传导

Jeffrey R Gehlhausen, Eric Hawley, Benjamin Mark Wahle, Yongzheng He, Donna Edwards, Steven D Rhodes, Jacquelyn D Lajiness, Karl Staser, Shi Chen, Xianlin Yang, Jin Yuan, Xiaohong Li, Li Jiang, Abbi Smith, Waylan Bessler, George Sandusky, Anat Stemmer-Rachamimov, Timothy J Stuhlmiller, Steven P Angu