日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer

基因组规模的 CRISPR 筛选发现 PTGES3 是晚期前列腺癌中雄激素受体功能的直接调节因子

Haolong Li,James E Melnyk,Becky Xu Hua Fu,Raunak Shrestha,Meng Zhang,Martin Sjöström,Siyu Feng,Jasmine A Anderson,Wanting Han,Lisa N Chesner,Hyun Jin Shin,Tatyanah Farsh,Humberto J Suarez,Seema Nath,Jonathan Chou,Rajdeep Das,Emily A Egusa,Marsha Calvert,Audrey Kishishita,Abhilash Barpanda,Jun Zhu,Ashutosh Maheshwari,William S Chen,Mohammed Alshalalfa,Aidan Winters,Junjie T Hua,Tianyi Liu,Elai Davicioni,Arun P Wiita,Bradley A Stohr,Javed Siddiqui,Bo Huang,Eric J Small,Kevan M Shokat,Peter S Nelson,David A Quigley,Elizabeth V Wasmuth,Luke A Gilbert,Felix Y Feng

Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer

综合分析突显了转移性前列腺癌中三维基因组与DNA、RNA和表观基因组改变之间的相互作用

Shuang G Zhao #,Matthew Bootsma #,Stanley Zhou #,Raunak Shrestha,Thaidy Moreno-Rodriguez,Arian Lundberg,Chu Pan,Christopher Arlidge,James R Hawley,Adam Foye,Alana S Weinstein,Martin Sjöström,Meng Zhang,Haolong Li,Lisa N Chesner,Nicholas R Rydzewski,Kyle T Helzer,Yue Shi,Joshua M Lang,Joshi J Alumkal,Hansen H He,Alexander W Wyatt,Rahul Aggarwal,Wilbert Zwart,Eric J Small,David A Quigley,Mathieu Lupien,Felix Y Feng

Genomic and transcriptomic features of androgen receptor signaling inhibitor resistance in metastatic castration-resistant prostate cancer

转移性去势抵抗性前列腺癌中雄激素受体信号抑制剂耐药性的基因组和转录组特征

Xiaolin Zhu, Tatyanah Farsh, Daniël Vis, Ivan Yu, Haolong Li, Tianyi Liu, Martin Sjöström, Raunak Shrestha, Jeroen Kneppers, Tesa Severson, Meng Zhang, Arian Lundberg, Thaidy Moreno Rodriguez, Alana S Weinstein, Adam Foye, Niven Mehra, Rahul R Aggarwal, Andries M Bergman, Eric J Small, Nathan A Lack

Immune Modulation with RANKL Blockade through Denosumab Treatment in Patients with Cancer

通过地舒单抗治疗癌症患者,以 RANKL 阻断剂进行免疫调节

Hewitt Chang, Jaqueline Marquez, Brandon K Chen, Daniel M Kim, Michael L Cheng, Eric V Liu, Hai Yang, Li Zhang, Meenal Sinha, Alexander Cheung, Serena S Kwek, Eric D Chow, Mark Bridge, Rahul R Aggarwal, Terence W Friedlander, Eric J Small, Mark Anderson, Lawrence Fong

Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer

小细胞神经内分泌前列腺癌中DLL3的免疫治疗靶向和PET成像

Jonathan Chou #,Emily A Egusa #,Sinan Wang #,Michelle L Badura,Fei Lee,Anil P Bidkar,Jun Zhu,Tanushree Shenoy,Kai Trepka,Troy M Robinson,Veronica Steri,Jiaoti Huang,Yuzhuo Wang,Eric J Small,Emily Chan,Bradley A Stohr,Alan Ashworth,Brant Delafontaine,Sylvie Rottey,Keegan S Cooke,Nooshin Hashemi Sadraei,Brian Yu,Mark Salvati,Julie M Bailis,Felix Y Feng,Robert R Flavell,Rahul Aggarwal

CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease

CUB 结构域蛋白 1 (CDCP1) 是去势抵抗性前列腺癌(包括 PSMA 基因缺失疾病)的放射配体治疗靶点

Ning Zhao, Shalini Chopra, Kai Trepka, Yung-Hua Wang, Sasank Sakhamuri, Nima Hooshdaran, Hyunjung Kim, Jie Zhou, Shion A Lim, Kevin K Leung, Emily A Egusa, Jun Zhu, Li Zhang, Adam Foye, Renuka Sriram, Emily Chan, Youngho Seo, Felix Y Feng, Eric J Small, Jonathan Chou, James A Wells, Rahul Aggarwal, 

The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression

CIC-ERF 共缺失是 ETS 家族成员 ETV1 融合独立激活的基础,进而推动前列腺癌进展

Nehal Gupta, Hanbing Song, Wei Wu, Rovingaile K Ponce, Yone K Lin, Ji Won Kim, Eric J Small, Felix Y Feng, Franklin W Huang, Ross A Okimoto

An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

综合功能和临床基因组学方法揭示了驱动侵袭性转移性前列腺癌的基因

Rajdeep Das, Martin Sjöström, Raunak Shrestha, Christopher Yogodzinski, Emily A Egusa, Lisa N Chesner, William S Chen, Jonathan Chou, Donna K Dang, Jason T Swinderman, Alex Ge, Junjie T Hua, Shaheen Kabir, David A Quigley, Eric J Small, Alan Ashworth, Felix Y Feng #, Luke A Gilbert #

Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer

转移性去势抵抗性前列腺癌患者对 sipuleucel-T 和 ipilimumab 联合治疗的反应与预先存在的免疫状态相关

Meenal Sinha, Li Zhang, Sumit Subudhi, Brandon Chen, Jaqueline Marquez, Eric V Liu, Kate Allaire, Alexander Cheung, Sharon Ng, Christopher Nguyen, Terence W Friedlander, Rahul Aggarwal, Matthew Spitzer, James P Allison, Eric J Small, Padmanee Sharma, Lawrence Fong

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

转移性前列腺癌的基因组特征和结构变异

David A Quigley ,Ha X Dang ,Shuang G Zhao ,Paul Lloyd ,Rahul Aggarwal ,Joshi J Alumkal ,Adam Foye ,Vishal Kothari ,Marc D Perry ,Adina M Bailey ,Denise Playdle ,Travis J Barnard ,Li Zhang ,Jin Zhang ,Jack F Youngren ,Marcin P Cieslik ,Abhijit Parolia ,Tomasz M Beer ,George Thomas ,Kim N Chi ,Martin Gleave ,Nathan A Lack ,Amina Zoubeidi ,Robert E Reiter ,Matthew B Rettig ,Owen Witte ,Charles J Ryan ,Lawrence Fong ,Won Kim ,Terence Friedlander ,Jonathan Chou ,Haolong Li ,Rajdeep Das ,Hui Li ,Ruhollah Moussavi-Baygi ,Hani Goodarzi ,Luke A Gilbert ,Primo N Lara Jr ,Christopher P Evans ,Theodore C Goldstein ,Joshua M Stuart ,Scott A Tomlins ,Daniel E Spratt ,R Keira Cheetham ,Donavan T Cheng ,Kyle Farh ,Julian S Gehring ,Jörg Hakenberg ,Arnold Liao ,Philip G Febbo ,John Shon ,Brad Sickler ,Serafim Batzoglou ,Karen E Knudsen ,Housheng H He ,Jiaoti Huang ,Alexander W Wyatt ,Scott M Dehm ,Alan Ashworth ,Arul M Chinnaiyan ,Christopher A Maher ,Eric J Small ,Felix Y Feng