日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial

轻度至中度阿尔茨海默病中的 p75 神经营养因子受体调节:一项随机、安慰剂对照的 2a 期试验

Hayley R C Shanks, Kewei Chen, Eric M Reiman, Kaj Blennow, Jeffrey L Cummings, Stephen M Massa, Frank M Longo, Anne Börjesson-Hanson, Manfred Windisch, Taylor W Schmitz

Single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease

阿尔茨海默病患者和非阿尔茨海默病患者的单细胞转录组和多尺度网络

Qi Wang, Jerry Antone, Eric Alsop, Rebecca Reiman, Cory Funk, Jaroslav Bendl, Joel T Dudley, Winnie S Liang, Timothy L Karr, Panos Roussos, David A Bennett, Philip L De Jager, Geidy E Serrano, Thomas G Beach, Kendall Van Keuren-Jensen, Diego Mastroeni, Eric M Reiman #, Benjamin P Readhead #

Molecular imaging of the association between serotonin degeneration and beta-amyloid deposition in mild cognitive impairment

轻度认知障碍中血清素退化和β-淀粉样蛋白沉积之间关联的分子成像

Gwenn S Smith, Hillary Protas, Hiroto Kuwabara, Alena Savonenko, Najlla Nassery, Neda F Gould, Michael Kraut, Dimitri Avramopoulos, Daniel Holt, Robert F Dannals, Ayon Nandi, Yi Su, Eric M Reiman, Kewei Chen

AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy

AR12 可增加 BAG3 表达,这对于通过 LC3 相关吞噬作用和巨自噬作用降解 Tau 和 APP 至关重要

Paul Dent, Laurence Booth, Jane L Roberts, Andrew Poklepovic, Jennifer Martinez, Derek Cridebring, Eric M Reiman

Genetic control of the human brain proteome

人类大脑蛋白质组的基因控制

Chloe Robins, Yue Liu, Wen Fan, Duc M Duong, Jacob Meigs, Nadia V Harerimana, Ekaterina S Gerasimov, Eric B Dammer, David J Cutler, Thomas G Beach, Eric M Reiman, Philip L De Jager, David A Bennett, James J Lah, Aliza P Wingo, Allan I Levey, Nicholas T Seyfried, Thomas S Wingo0

Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure

在血清暴露下,用人脑类器官模拟散发性阿尔茨海默病

Xianwei Chen, Guoqiang Sun, E Tian, Mingzi Zhang, Hayk Davtyan, Thomas G Beach, Eric M Reiman, Mathew Blurton-Jones, David M Holtzman, Yanhong Shi

Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43

抑制热休克蛋白可增加自噬体形成,并降低 APP、Tau、SOD1 G93A 和 TDP-43 的表达

Paul Dent, Laurence Booth, Jane L Roberts, Andrew Poklepovic, Derek Cridebring, Eric M Reiman

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

阿尔茨海默病大脑和脑脊液的大规模蛋白质组学分析揭示了与小胶质细胞和星形胶质细胞活化相关的能量代谢早期变化

Erik C B Johnson #, Eric B Dammer #, Duc M Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A Higginbotham, Andrew Guajardo, Bartholomew White, Juan C Troncoso, Madhav Thambisetty, Thomas J Montine, Edward B Lee, John Q Trojanowski, Thomas G Beach, Eric M Reiman, Vahram Haroutunian, Minghui Wan

Effect of ApoE isoforms on mitochondria in Alzheimer disease

ApoE 亚型对阿尔茨海默病线粒体的影响

Junxiang Yin, Eric M Reiman, Thomas G Beach, Geidy E Serrano, Marwan N Sabbagh, Megan Nielsen, Richard J Caselli, Jiong Shi

Human Autopsy-Derived Scalp Fibroblast Biobanking for Age-Related Neurodegenerative Disease Research

人类尸检来源的头皮成纤维细胞生物库用于与年龄相关的神经退行性疾病研究

Suet Theng Beh, Carlye Frisch, David A Brafman, Jared Churko, Jessica E Walker, Geidy E Serrano, Lucia I Sue, Eric M Reiman, Thomas G Beach, Lih-Fen Lue