日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence

结构引导发现具有序列上下文独立性的高效胞苷脱氨酶

Kui Xu #, Hu Feng #, Haihang Zhang #, Chenfei He #, Huifang Kang #, Tanglong Yuan, Lei Shi, Chikai Zhou, Guoying Hua, Yaqi Cao, Zhenrui Zuo, Erwei Zuo

Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

设计出没有基序偏好和腺苷活性限制的TadA直系同源物衍生的胞嘧啶碱基编辑器

Guoling Li #, Xue Dong #, Jiamin Luo #, Tanglong Yuan #, Tong Li #, Guoli Zhao #, Hainan Zhang, Jingxing Zhou, Zhenhai Zeng, Shuna Cui, Haoqiang Wang, Yin Wang, Yuyang Yu, Yuan Yuan, Erwei Zuo, Chunlong Xu, Jinhai Huang, Yingsi Zhou

Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes

结合DNA序列以外的内源性因素的深度学习模型提高了碱基编辑结果的预测准确性

Tanglong Yuan #,Leilei Wu #,Shiyan Li #,Jitan Zheng #,Nana Li #,Xiao Xiao #,Haihang Zhang,Tianyi Fei,Long Xie,Zhenrui Zuo,Di Li,Pinzheng Huang,Hu Feng,Yaqi Cao,Nana Yan,Xinming Wei,Lei Shi,Yongsen Sun,Wu Wei,Yidi Sun,Erwei Zuo

Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells

腺嘌呤碱基编辑器诱导小鼠胚胎和人类原代 T 细胞脱靶结构变异

Leilei Wu #, Shutan Jiang #, Meisong Shi #, Tanglong Yuan, Yaqin Li, Pinzheng Huang, Yingqi Li, Erwei Zuo, Changyang Zhou, Yidi Sun

Undetectable off-target effects induced by FokI catalytic domain in mouse embryos

FokI 催化结构域在小鼠胚胎中诱导的脱靶效应不可检测

Long Xie #, Hu Feng #, Zhifang Li #, Di Li #, Xiali Yang, Tanglong Yuan, Nana Yan, Chenfei He, Jitan Zheng, Zhenrui Zuo, Yaxuan Zheng, Yaqi Cao, Yangqing Lu, Xing Yao Xiong, Erwei Zuo

An ovalbumin fusion strategy to increase recombinant protein secretion in chicken eggs

增加鸡蛋中重组蛋白分泌的卵清蛋白融合策略

Long Xie #, Zhenwen Huang #, Meiyu Lan #, Yaqi Cao #, Lingling Sun, Lang Zhang, Erwei Zuo, Yangqing Lu

FokI-RYdCas9 Mediates Nearly PAM-Less and High-Precise Gene Editing in Human Cells

FokI-RYdCas9 可在人类细胞中实现几乎无 PAM 且高精度的基因编辑

Di Li, Yaqi Cao, Long Xie, Chenfei He, Danrong Jiao, Mengxue Ma, Zhenrui Zuo, Erwei Zuo, Xiaogan Yang

Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice

胞嘧啶碱基编辑器在转基因小鼠中诱发脱靶突变和不良表型效应

Nana Yan #, Hu Feng #, Yongsen Sun #, Ying Xin #, Haihang Zhang #, Hongjiang Lu, Jitan Zheng, Chenfei He, Zhenrui Zuo, Tanglong Yuan, Nana Li, Long Xie, Wu Wei, Yidi Sun, Erwei Zuo

Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor

人类 8 细胞胚胎能够有效诱导疾病预防突变,且不会因胞嘧啶碱基编辑器产生脱靶效应

Yinghui Wei, Meiling Zhang, Jing Hu, Yingsi Zhou, Mingxing Xue, Jianhang Yin, Yuanhua Liu, Hu Feng, Ling Zhou, Zhifang Li, Dongshuang Wang, Zhiguo Zhang, Yin Zhou, Hongbin Liu, Ning Yao, Erwei Zuo, Jiazhi Hu, Yanzhi Du, Wen Li, Chunlong Xu, Hui Yang

Mini-dCas13X-mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy

Mini-dCas13X 介导的 RNA 编辑可恢复杜氏肌营养不良症人源化小鼠模型中的肌营养不良蛋白表达

Guoling Li, Ming Jin, Zhifang Li, Qingquan Xiao, Jiajia Lin, Dong Yang, Yuanhua Liu, Xing Wang, Long Xie, Wenqin Ying, Haoqiang Wang, Erwei Zuo, Linyu Shi, Ning Wang, Wanjin Chen, Chunlong Xu, Hui Yang