日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.

利用分子动力学模拟鉴定与 Gq/11 蛋白通路和 β-阻遏蛋白通路相关的血管紧张素 II 1 型受体的不同构象

Cabana Jérôme, Holleran Brian, Leduc Richard, Escher Emanuel, Guillemette Gaétan, Lavigne Pierre

Structure of the human angiotensin II type 1 (AT1) receptor bound to angiotensin II from multiple chemoselective photoprobe contacts reveals a unique peptide binding mode.

通过多个化学选择性光探针接触,揭示了与血管紧张素 II 结合的人类血管紧张素 II 1 型 (AT1) 受体的结构,展现了一种独特的肽结合模式

Fillion Dany, Cabana Jérôme, Guillemette Gaétan, Leduc Richard, Lavigne Pierre, Escher Emanuel

Agonists for the Chemokine Receptor CXCR4

趋化因子受体CXCR4的激动剂

Lefrançois, Marilou; Lefebvre, Marie-Reine; Saint-Onge, Geneviève; Boulais, Philip E; Lamothe, Simon; Leduc, Richard; Lavigne, Pierre; Heveker, Nikolaus; Escher, Emanuel

The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activation

人I型血管紧张素II受体的第二个跨膜结构域参与配体结合口袋的形成,并在受体激活过程中发生整体枢轴运动。

Domazet, Ivana; Holleran, Brian J; Martin, Stéphane S; Lavigne, Pierre; Leduc, Richard; Escher, Emanuel; Guillemette, Gaétan

The fifth transmembrane domain of angiotensin II Type 1 receptor participates in the formation of the ligand-binding pocket and undergoes a counterclockwise rotation upon receptor activation

血管紧张素II 1型受体的第五个跨膜结构域参与配体结合口袋的形成,并在受体激活后发生逆时针旋转。

Domazet, Ivana; Martin, Stéphane S; Holleran, Brian J; Morin, Marie-Eve; Lacasse, Patrick; Lavigne, Pierre; Escher, Emanuel; Leduc, Richard; Guillemette, Gaétan

Surface Plasmon Resonance Monitoring of Cell Monolayer Integrity: Implication of Signaling Pathways Involved in Actin-Driven Morphological Remodeling

利用表面等离子体共振监测细胞单层完整性:肌动蛋白驱动的形态重塑信号通路的意义

Cuerrier, Charles M; Chabot, Vincent; Vigneux, Sylvain; Aimez, Vincent; Escher, Emanuel; Gobeil, Fernand; Charette, Paul G; Grandbois, Michel

Photolabelling the urotensin II receptor reveals distinct agonist- and partial-agonist-binding sites

对尿张素II受体进行光标记,可揭示其不同的激动剂和部分激动剂结合位点。

Holleran, Brian J; Beaulieu, Marie-Eve; Proulx, Christophe D; Lavigne, Pierre; Escher, Emanuel; Leduc, Richard

Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization

胞质尾丝氨酸簇参与尿张素II受体内化

Proulx, Christophe D; Simaan, May; Escher, Emanuel; Laporte, Stéphane A; Guillemette, Gaétan; Leduc, Richard

Importance of N-glycosylation positioning for cell-surface expression, targeting, affinity and quality control of the human AT1 receptor

N-糖基化定位对人AT1受体的细胞表面表达、靶向、亲和力和质量控制的重要性

Lanctot, Pascal M; Leclerc, Patrice C; Clément, Martin; Auger-Messier, Mannix; Escher, Emanuel; Leduc, Richard; Guillemette, Gaétan

Photolabelling the rat urotensin II/GPR14 receptor identifies a ligand-binding site in the fourth transmembrane domain

对大鼠尿张素II/GPR14受体进行光标记,可鉴定出第四个跨膜结构域中的配体结合位点。

Boucard, Antony A; Sauvé, Simon S; Guillemette, Gaétan; Escher, Emanuel; Leduc, Richard