日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors

针对 ADAM9 表达肿瘤的下一代美登木素抗体药物偶联物 IMGC936 的临床前评估

Juniper A Scribner #, Stuart W Hicks #, Kerstin W Sinkevicius, Nicholas C Yoder, Gundo Diedrich, Jennifer G Brown, Jacquelynn Lucas, Megan E Fuller, Thomas Son, Anahita Dastur, Jeff Hooley, Christopher Espelin, Marian Themeles, Francine Z Chen, Ying Li, Michael Chiechi, Jenny Lee, Bhaswati Barat, Lu

Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody-Drug Conjugates to Increase In Vivo Efficacy

抗体联合给药可改善抗体-药物偶联物的全身和局部分布,从而提高体内疗效。

Ponte, Jose F; Lanieri, Leanne; Khera, Eshita; Laleau, Rassol; Ab, Olga; Espelin, Christopher; Kohli, Neeraj; Matin, Bahar; Setiady, Yulius; Miller, Michael L; Keating, Thomas A; Chari, Ravi; Pinkas, Jan; Gregory, Richard; Thurber, Greg M

Multiscale kinetic modeling of liposomal Doxorubicin delivery quantifies the role of tumor and drug-specific parameters in local delivery to tumors

脂质体阿霉素递送的多尺度动力学模型量化了肿瘤和药物特异性参数在局部肿瘤递送中的作用

Hendriks, B S; Reynolds, J G; Klinz, S G; Geretti, E; Lee, H; Leonard, S C; Gaddy, D F; Espelin, C W; Nielsen, U B; Wickham, T J

Molecular structures and interactions in the yeast kinetochore

酵母着丝粒的分子结构和相互作用

Cho, U-S; Corbett, K D; Al-Bassam, J; Bellizzi, J J 3rd; De Wulf, P; Espelin, C W; Miranda, J J; Simons, K; Wei, R R; Sorger, P K; Harrison, S C

Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line

升高的 GM-CSF 和 IL-1beta 水平会削弱 p38 MAPK 抑制剂调节人类单核细胞/巨噬细胞 U937 细胞系中 TNFalpha 水平的能力

Christopher W Espelin, Arthur Goldsipe, Peter K Sorger, Douglas A Lauffenburger, David de Graaf, Bart S Hendriks

Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII

酿酒酵母必需的着丝粒蛋白Ndc10p与CDEII的结合

Espelin, Christopher W; Simons, Kim T; Harrison, Stephen C; Sorger, Peter K