日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

NK cell subsets define sustained remission in rheumatoid arthritis

NK细胞亚群定义了类风湿性关节炎的持续缓解

Carl Coyle ,Margaret Ma ,Yann Abraham ,Christopher B Mahony ,Kathryn Steel ,Catherine Simpson ,Nadia Guerra ,Adam P Croft ,Stephen Rapecki ,Andrew Cope ,Rowann Bowcutt ,Esperanza Perucha

Regulatory B cell repertoire defects predispose lung cancer patients to immune-related toxicity following checkpoint blockade

调节性 B 细胞库缺陷使肺癌患者在接受检查点阻断治疗后易出现免疫相关毒性

Akshay J Patel, Zena N Willsmore, Naeem Khan, Alex Richter, Babu Naidu, Mark T Drayson, Sophie Papa, Andrew Cope, Sophia N Karagiannis, Esperanza Perucha, Gary W Middleton

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

胆固醇代谢通过提供牻牛儿基焦磷酸酯来驱动调节性B细胞IL-10的产生。

Jack A Bibby ,Harriet A Purvis ,Thomas Hayday ,Anita Chandra ,Klaus Okkenhaug ,Sofia Rosenzweig ,Ivona Aksentijevich ,Michael Wood ,Helen J Lachmann ,Claudia Kemper ,Andrew P Cope # ,Esperanza Perucha #

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease

遗传变异改变粘膜炎症疾病中的 T-bet 结合和基因表达

Katrina Soderquest, Arnulf Hertweck, Claudia Giambartolomei, Stephen Henderson, Rami Mohamed, Rimma Goldberg, Esperanza Perucha, Lude Franke, Javier Herrero, Vincent Plagnol, Richard G Jenner, Graham M Lord

Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation

白细胞介素 6 可增加小鼠和慢性肠道炎症患者结肠固有淋巴细胞的细胞因子产生

Nick Powell ,Jonathan W Lo ,Paolo Biancheri ,Anna Vossenkämper ,Eirini Pantazi ,Alan W Walker ,Emilie Stolarczyk ,Francesca Ammoscato ,Rimma Goldberg ,Paul Scott ,James B Canavan ,Esperanza Perucha ,Natividad Garrido-Mesa ,Peter M Irving ,Jeremy D Sanderson ,Bu Hayee ,Jane K Howard ,Julian Parkhill ,Thomas T MacDonald ,Graham M Lord

C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

C3a 通过调节 ATP 外流和随后的 NLRP3 炎症小体激活来调节人类单核细胞中的 IL-1β 分泌

Elham Asgari, Gaelle Le Friec, Hidekazu Yamamoto, Esperanza Perucha, Steven S Sacks, Jörg Köhl, H Terence Cook, Claudia Kemper

Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4

全基因组调控分析表明,T-bet 通过直接抑制 IRF4 来控制 Th17 谱系分化

M Refik Gökmen, Rong Dong, Aditi Kanhere, Nick Powell, Esperanza Perucha, Ian Jackson, Jane K Howard, Maria Hernandez-Fuentes, Richard G Jenner, Graham M Lord

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements

T-bet 和 GATA3 通过谱系特异性靶向远端调节元件来协调 Th1 和 Th2 分化

Aditi Kanhere, Arnulf Hertweck, Urvashi Bhatia, M Refik Gökmen, Esperanza Perucha, Ian Jackson, Graham M Lord, Richard G Jenner

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

开发跨平台生物标志物特征来检测人类肾脏移植耐受性

Pervinder Sagoo, Esperanza Perucha, Birgit Sawitzki, Stefan Tomiuk, David A Stephens, Patrick Miqueu, Stephanie Chapman, Ligia Craciun, Ruhena Sergeant, Sophie Brouard, Flavia Rovis, Elvira Jimenez, Amany Ballow, Magali Giral, Irene Rebollo-Mesa, Alain Le Moine, Cecile Braudeau, Rachel Hilton, Bernh