Deficient de-S-acylation in aging and CLN1 contributes to lyso-mitochondrial dysfunction, lipid dyshomeostasis, and resultant lipofuscin biogenesis.
衰老和 CLN1 中去 S-酰化不足会导致溶酶体-线粒体功能障碍、脂质稳态失衡以及由此产生的脂褐素生物合成。
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doi:10.21203/rs.3.rs-8770768/v1
Tieze Sofia Massaro, Esqueda Alexander, McAllister Rachel, Lagator Matija, Yücel Betül, Sun Eric, Lam TuKiet T, Lockyer Nicholas, Gupta Kallol, Chandra Sreeganga S
