日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Design, synthesis, and antiproliferative activity of new 2-amino-pyrano[3,2-c]quinoline-3-carbonitriles as potential EGFR, BRAF(V600E), and HER-2 inhibitors

新型2-氨基吡喃并[3,2-c]喹啉-3-腈类化合物的设计、合成及其作为潜在EGFR、BRAF(V600E)和HER-2抑制剂的抗增殖活性

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra04276c
Al-Wahaibi, Lamya H; Mohassab, Aliaa M; Rabea, Safwat M; Youssif, Bahaa G M; Bräse, Stefan; El-Sheref, Essmat M
EGFR
EGF
BRAF
发表日期：2025
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Convenient synthesis and X-ray determination of 2-amino-6H-1,3,4-thiadiazin-3-ium bromides endowed with antiproliferative activity

简便合成及X射线测定具有抗增殖活性的2-氨基-6H-1,3,4-噻二嗪-3-溴化物

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d4ra02531h
Tawfeek, Hendawy N; Abdelmoez, Alshaimaa; Dahlous, Kholood A; Youssif, Bahaa G M; Bräse, Stefan; Rissanen, Kari; Nieger, Martin; El-Sheref, Essmat M
发表日期：2024
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Stereoselective synthesis and X-ray structure determination of novel 1,2-dihydroquinolinehydrazonopropanoate derivatives

新型1,2-二氢喹啉腙丙酸酯衍生物的立体选择性合成及X射线结构测定

期刊:Heliyon
影响因子:3.6
doi:10.1016/j.heliyon.2024.e25248
Tawfeek, Hendawy N; Tawfeek, Ahmed M; Bräse, Stefan; Nieger, Martin; El-Sheref, Essmat M
发表日期：2024
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Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF(V600E) inhibitors

合成一系列具有凋亡抑制和抗增殖作用的新型4-吡唑基喹啉酮类化合物，作为双重EGFR/BRAF(V600E)抑制剂

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d4md00230j
Al-Wahaibi, Lamya H; Youssif, Bahaa G M; Abou-Zied, Hesham A; Bräse, Stefan; Brown, Alan B; Tawfeek, Hendawy N; El-Sheref, Essmat M
EGFR
BRAF
表观遗传
EGF
凋亡
发表日期：2024
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Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors

4-(1,2,3-三唑-1-基)喹啉-2(1H)-酮作为多靶点抑制剂的合成、抗氧化和抗增殖作用

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms241713300
El-Sheref, Essmat M; Bräse, Stefan; Tawfeek, Hendawy N; Alasmary, Fatmah Ali; Youssif, Bahaa G M
发表日期：2023
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One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAF(V600E) Inhibitors

通过席夫碱一锅法合成1-噻唑-4-氮杂螺[4.4/5]烷-3-酮：双重EGFR/BRAF(V600E)抑制剂的设计、合成及其抗凋亡增殖特性

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph16030467
Al-Wahaibi, Lamya H; El-Sheref, Essmat M; Hammouda, Mohamed M; Youssif, Bahaa G M
EGFR
EGF
表观遗传
凋亡
BRAF
发表日期：2023
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Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF(V600E) Dual Inhibitors Endowed with Antiproliferative Activity

合成及结构鉴定取代噻唑衍生物作为具有抗增殖活性的EGFR/BRAF(V600E)双重抑制剂

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph16071014
Al-Wahaibi, Lamya H; El-Sheref, Essmat M; Hassan, Alaa A; Bräse, S; Nieger, M; Youssif, Bahaa G M; Ibrahim, Mahmoud A A; Tawfeek, Hendawy N
EGFR
BRAF
EGF
发表日期：2023
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Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action

设计、合成及生物学评价含二羟基萘部分的Syn和Anti样双弹头喹啉酮类化合物作为表皮生长因子受体抑制剂及其潜在的凋亡抗增殖活性

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules27248765
El-Sheref, Essmat M; Ameen, Mohamed A; El-Shaieb, Kamal M; Abdel-Latif, Fathy F; Abdel-Naser, Asmaa I; Brown, Alan B; Bräse, Stefan; Fathy, Hazem M; Ahmad, Iqrar; Patel, Harun; Gomaa, Hesham A M; Youssif, Bahaa G M; Mohamed, Asmaa H
表观遗传
信号转导
凋亡
发表日期：2022
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Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties

通过一锅三组分反应合成新型脒类化合物：具有抗增殖特性的选择性拓扑异构酶I抑制剂

期刊:Frontiers in Chemistry
影响因子:4.2
doi:10.3389/fchem.2022.1039176
El-Sheref, Essmat M; Tawfeek, Hendawy N; Hassan, Alaa A; Bräse, S; Elbastawesy, Mohammed A I; Gomaa, Hesham A M; Mostafa, Yaser A; Youssif, Bahaa G M
发表日期：2022
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Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents

通过点击反应设计合成(2-氧代-1,2-二氢喹啉-4-基)-1,2,3-三唑衍生物：潜在的凋亡抑制抗增殖剂

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules26226798
El-Sheref, Essmat M; Elbastawesy, Mohammed A I; Brown, Alan B; Shawky, Ahmed M; Gomaa, Hesham A M; Bräse, Stefan; Youssif, Bahaa G M
表观遗传
凋亡
发表日期：2021
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