Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers
IAG933通过直接和选择性地药理学手段破坏YAP-TEAD界面，从而抑制Hippo依赖性和RAS-MAPK改变的癌症。
期刊:Nature Cancer
影响因子:23.5
doi:10.1038/s43018-024-00754-9
Emilie A Chapeau ,Laurent Sansregret ,Giorgio G Galli ,Patrick Chène ,Markus Wartmann ,Thanos P Mourikis ,Patricia Jaaks ,Sabrina Baltschukat ,Ines A M Barbosa ,Daniel Bauer ,Saskia M Brachmann ,Clara Delaunay ,Claire Estadieu ,Jason E Faris ,Pascal Furet ,Stefanie Harlfinger ,Andreas Hueber ,Eloísa Jiménez Núñez ,David P Kodack ,Emeline Mandon ,Typhaine Martin ,Yannick Mesrouze ,Vincent Romanet ,Clemens Scheufler ,Holger Sellner ,Christelle Stamm ,Dario Sterker ,Luca Tordella ,Francesco Hofmann ,Nicolas Soldermann ,Tobias Schmelzle
RAS
YAP
肿瘤免疫
MAPK/ERK
Hippo
肿瘤
