日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.

通过深度突变扫描绘制MET受体酪氨酸激酶的激酶结构域抗性机制图谱

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.101882
Estevam Gabriella O, Linossi Edmond, Rao Jingyou, Macdonald Christian B, Ravikumar Ashraya, Chrispens Karson M, Capra John A, Coyote-Maestas Willow, Pimentel Harold, Collisson Eric A, Jura Natalia, Fraser James S
其它
发表日期：2025
文献求助 收藏

MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation.

在遗传性乳头状肾细胞癌中发现的具有激活 N 叶突变的 MET 变体仍然需要配体刺激

期刊:Molecular Oncology
影响因子:4.5
doi:10.1002/1878-0261.13806
Guérin Célia, Vinchent Audrey, Fernandes Marie, Damour Isabelle, Laratte Agathe, Tellier Rémi, Estevam Gabriella O, Meneboo Jean-Pascal, Villenet Céline, Descarpentries Clotilde, Fraser James S, Figeac Martin, Cortot Alexis B, Rouleau Etienne, Tulasne David
细胞生物学
肿瘤免疫
发表日期：2025
文献求助 收藏

Engineering of CRISPR-Cas PAM recognition using deep learning of vast evolutionary data

利用深度学习对海量进化数据进行CRISPR-Cas PAM识别的工程改造

期刊:
影响因子:
doi:10.1101/2025.01.06.631536
Nayfach, Stephen; Bhatnagar, Aadyot; Novichkov, Andrey; Estevam, Gabriella O; Kim, Nahye; Hill, Emily; Ruffolo, Jeffrey A; Silverstein, Rachel; Gallagher, Joseph; Kleinstiver, Benjamin; Meeske, Alexander J; Cameron, Peter; Madani, Ali
发表日期：2025
文献求助 收藏

Autoregulation of the MET receptor tyrosine kinase by its intracellular juxtamembrane domain

MET受体酪氨酸激酶通过其胞内近膜结构域进行自身调节

期刊:Biochemical Journal
影响因子:
doi:10.1042/BCJ20253378
Linossi, Edmond M; Espinoza, Carla A; Estevam, Gabriella O; Fraser, James S; Jura, Natalia
信号转导
MET
发表日期：2025
文献求助 收藏

Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage

Rosace：一种采用位置和均值-方差收缩的稳健深度突变扫描分析框架

期刊:Genome Biology
影响因子:9.4
doi:10.1186/s13059-024-03279-7
Rao, Jingyou; Xin, Ruiqi; Macdonald, Christian; Howard, Matthew K; Estevam, Gabriella O; Yee, Sook Wah; Wang, Mingsen; Fraser, James S; Coyote-Maestas, Willow; Pimentel, Harold
发表日期：2024
文献求助 收藏

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

通过对MET受体酪氨酸激酶结构域进行深度突变扫描，揭示了近膜结构域和激酶N叶中的保守调控基序。

期刊:
影响因子:
doi:10.1101/2023.08.03.551866
Estevam, Gabriella O; Linossi, Edmond M; Macdonald, Christian B; Espinoza, Carla A; Michaud, Jennifer M; Coyote-Maestas, Willow; Collisson, Eric A; Jura, Natalia; Fraser, James S
信号转导
MET
发表日期：2024
文献求助 收藏

State of the structure address on MET receptor activation by HGF

HGF激活MET受体的结构地址状态

期刊:Biochemical Society Transactions
影响因子:4.3
doi:10.1042/BST20200394
Linossi, Edmond M; Estevam, Gabriella O; Oshima, Masaya; Fraser, James S; Collisson, Eric A; Jura, Natalia
信号转导
HGF
MET
发表日期：2021
文献求助 收藏