日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

妊娠期肝内胆汁淤积症的全基因组关联研究(GWAS)荟萃分析表明,多个肝脏基因和调控元件与该疾病相关。

Dixon, Peter H; Levine, Adam P; Cebola, Inês; Chan, Melanie M Y; Amin, Aliya S; Aich, Anshul; Mozere, Monika; Maude, Hannah; Mitchell, Alice L; Zhang, Jun; Chambers, Jenny; Syngelaki, Argyro; Donnelly, Jennifer; Cooley, Sharon; Geary, Michael; Nicolaides, Kypros; Thorsell, Malin; Hague, William M; Estiu, Maria Cecilia; Marschall, Hanns-Ulrich; Gale, Daniel P; Williamson, Catherine

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

发现选择性小分子 HDAC6 抑制剂,可克服多发性骨髓瘤中的蛋白酶体抑制剂耐药性

Teru Hideshima, Jun Qi, Ronald M Paranal, Weiping Tang, Edward Greenberg, Nathan West, Meaghan E Colling, Guillermina Estiu, Ralph Mazitschek, Jennifer A Perry, Hiroto Ohguchi, Francesca Cottini, Naoya Mimura, Güllü Görgün, Yu-Tzu Tai, Paul G Richardson, Ruben D Carrasco, Olaf Wiest, Stuart L Schrei

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

恶性疟原虫疟疾青蒿素抗性的分子机制

Alassane Mbengue, Souvik Bhattacharjee, Trupti Pandharkar, Haining Liu, Guillermina Estiu, Robert V Stahelin, Shahir S Rizk, Dieudonne L Njimoh, Yana Ryan, Kesinee Chotivanich, Chea Nguon, Mehdi Ghorbal, Jose-Juan Lopez-Rubio, Michael Pfrender, Scott Emrich, Narla Mohandas, Arjen M Dondorp, Olaf Wie

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

疟原虫胞质脯氨酰-tRNA合成酶是费布芬及其类似物的双阶段靶点

Herman, Jonathan D; Pepper, Lauren R; Cortese, Joseph F; Estiu, Guillermina; Galinsky, Kevin; Zuzarte-Luis, Vanessa; Derbyshire, Emily R; Ribacke, Ulf; Lukens, Amanda K; Santos, Sofia A; Patel, Vishal; Clish, Clary B; Sullivan, William J Jr; Zhou, Huihao; Bopp, Selina E; Schimmel, Paul; Lindquist, Susan; Clardy, Jon; Mota, Maria M; Keller, Tracy L; Whitman, Malcolm; Wiest, Olaf; Wirth, Dyann F; Mazitschek, Ralph

Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs

等排噻唑啉-噁唑大唑类似物的合成及其HDAC抑制活性

Guerra-Bubb, Jennifer M; Bowers, Albert A; Smith, William B; Paranal, Ronald; Estiu, Guillermina; Wiest, Olaf; Bradner, James E; Williams, Robert M

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

选择性抑制剂对 DOT1L 甲基转移酶催化位点进行重塑

Wenyu Yu, Emma J Chory, Amy K Wernimont, Wolfram Tempel, Alex Scopton, Alexander Federation, Jason J Marineau, Jun Qi, Dalia Barsyte-Lovejoy, Joanna Yi, Richard Marcellus, Roxana E Iacob, John R Engen, Carly Griffin, Ahmed Aman, Erno Wienholds, Fengling Li, Javier Pineda, Guillermina Estiu, Tatiana

Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probes

利用激动剂作为计算探针,鉴定β2-肾上腺素能受体的配体结合构象

Isin, Basak; Estiu, Guillermina; Wiest, Olaf; Oltvai, Zoltán N

Catalyzed decomposition of urea. Molecular dynamics simulations of the binding of urea to urease

尿素的催化分解。尿素与脲酶结合的分子动力学模拟

Estiu, Guillermina; Merz, Kenneth M Jr