The absence of Parkin in hTau mice leads to synaptic mitochondrial dysfunction, alterations to the synaptic proteome, and increased phosphorylated tau in the Hippocampus
hTau小鼠中Parkin的缺失会导致突触线粒体功能障碍、突触蛋白质组改变以及海马中磷酸化tau蛋白增加。
期刊:Neurobiology of Disease
影响因子:5.6
doi:10.1016/j.nbd.2025.107084
Estrella, L Daniel; Xu, Xiaoke; White, Collin; Manganaro, Jane E; Sheldon, Lexi; Farmer, Trey; Stauch, Kelly L
信号转导
神经科学
线粒体
Parkin
磷酸化
Hippo
