日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy

长效人生长激素-Fc融合蛋白的工程改造:价态、融合位置和连接子设计对药代动力学和疗效的影响

Lee, Taekyeol; Lee, Dongsop; Jung, Eunee; Son, Mikyung; Koo, Kyohwan; Choi, Jaehoon

Mosaicism-independent mechanisms contribute to Pcdh19-related epilepsy and repetitive behaviors in Xenopus

不依赖嵌合体的机制导致非洲爪蟾 Pcdh19 相关癫痫和重复行为

Jugeon Park, Eunee Lee, Chul Hoon Kim, Jiyeon Ohk, Hosung Jung

A machine learning-based quantitative model (LogBB_Pred) to predict the blood-brain barrier permeability (logBB value) of drug compounds

一种基于机器学习的定量模型(LogBB_Pred),用于预测药物化合物的血脑屏障通透性(logBB值)。

Shaker, Bilal; Lee, Jingyu; Lee, Yunhyeok; Yu, Myeong-Sang; Lee, Hyang-Mi; Lee, Eunee; Kang, Hoon-Chul; Oh, Kwang-Seok; Kim, Hyung Wook; Na, Dokyun

Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice.

IRSp53突变小鼠的前额叶神经元放电变异性受到抑制,社会表征能力受损

Kim Woohyun, Shin Jae Jin, Jeong Yu Jin, Kim Kyungdeok, Bae Jung Won, Noh Young Woo, Lee Seungjoon, Choi Woochul, Paik Se-Bum, Jung Min Whan, Lee Eunee, Kim Eunjoon

Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

兴奋性突触和间隙连接协同作用,改善 Shank2 突变小鼠的 Pv 神经元爆发放电和皮质社会认知

Eunee Lee #, Seungjoon Lee #, Jae Jin Shin #, Woochul Choi #, Changuk Chung, Suho Lee, Jihye Kim, Seungmin Ha, Ryunhee Kim, Taesun Yoo, Ye-Eun Yoo, Jisoo Kim, Young Woo Noh, Issac Rhim, Soo Yeon Lee, Woohyun Kim, Taekyung Lee, Hyogeun Shin, Il-Joo Cho, Karl Deisseroth, Sang Jeong Kim, Joo Min Park, 

Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex of Shank2-Mutant Mice

Shank2突变小鼠前额叶皮层中基因剂量和年龄依赖性的差异转录组变化

Lee, Seungjoon; Kang, Hyojin; Jung, Hwajin; Kim, Eunjoon; Lee, Eunee

Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2(-/-) Mice

早期纠正N-甲基-D-天冬氨酸受体功能可改善成年Shank2(-/-)小鼠的自闭症样社交行为

Chung, Changuk; Ha, Seungmin; Kang, Hyojin; Lee, Jiseok; Um, Seung Min; Yan, Haidun; Yoo, Ye-Eun; Yoo, Taesun; Jung, Hwajin; Lee, Dongwon; Lee, Eunee; Lee, Seungjoon; Kim, Jihye; Kim, Ryunhee; Kwon, Yonghan; Kim, Woohyun; Kim, Hyosang; Duffney, Lara; Kim, Doyoun; Mah, Won; Won, Hyejung; Mo, Seojung; Kim, Jin Yong; Lim, Chae-Seok; Kaang, Bong-Kiun; Boeckers, Tobias M; Chung, Yeonseung; Kim, Hyun; Jiang, Yong-Hui; Kim, Eunjoon

NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors

NGL-3 在大脑发育、Akt/GSK3b 信号传导、长期抑制以及运动和认知行为的调控中发挥作用

Lee, Hyejin; Shin, Wangyong; Kim, Kyungdeok; Lee, Suho; Lee, Eun-Jae; Kim, Jihye; Kweon, Hanseul; Lee, Eunee; Park, Haram; Kang, Muwon; Yang, Esther; Kim, Hyun; Kim, Eunjoon

Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes

小鼠中细胞类型特异性 Shank2 缺失导致不同的突触和行为表型

Ryunhee Kim, Jihye Kim, Changuk Chung, Seungmin Ha, Seungjoon Lee, Eunee Lee, Ye-Eun Yoo, Woohyun Kim, Wangyong Shin, Eunjoon Kim

Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice

小清蛋白神经元中的 Shank2 缺失导致小鼠中度多动、自我梳理增强和癫痫易感性抑制

Seungjoon Lee, Eunee Lee, Ryunhee Kim, Jihye Kim, Suho Lee, Haram Park, Esther Yang, Hyun Kim, Eunjoon Kim