日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure

TYRP1-TCB (RO7293583) 是一种新型 TYRP1 靶向 CD3 T 细胞接合剂,用于治疗转移性黑色素瘤,开展第 1 阶段首次人体研究:主动药物监测以评估免疫反应对药物暴露的影响

Anna Spreafico, Eva Muñoz Couselo, Anja Irmisch, Juliana Bessa, George Au-Yeung, Oliver Bechter, Inge Marie Svane, Miguel F Sanmamed, Valentina Gambardella, Meredith McKean, Margaret Callahan, Reinhard Dummer, Christian Klein, Pablo Umaña, Nicole Justies, Florian Heil, Linda Fahrni, Eugenia Opolka-H

Exploring the Immunogenicity of Noncanonical HLA-I Tumor Ligands Identified through Proteogenomics

通过蛋白质组学探索非经典HLA-I肿瘤配体的免疫原性

Maria Lozano-Rabella ,Andrea Garcia-Garijo ,Jara Palomero ,Anna Yuste-Estevanez ,Florian Erhard ,Roc Farriol-Duran ,Juan Martín-Liberal ,Maria Ochoa-de-Olza ,Ignacio Matos ,Jared J Gartner ,Michael Ghosh ,Francesc Canals ,August Vidal ,Josep Maria Piulats ,Xavier Matías-Guiu ,Irene Brana ,Eva Muñoz-Couselo ,Elena Garralda ,Andreas Schlosser ,Alena Gros

BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy

代谢应激激活 BRAF 可促进糖酵解,使 NRASQ61 突变黑色素瘤对靶向治疗敏感

Kimberley McGrail, Paula Granado-Martínez, Rosaura Esteve-Puig, Sara García-Ortega, Yuxin Ding, Sara Sánchez-Redondo, Berta Ferrer, Javier Hernandez-Losa, Francesc Canals, Anna Manzano, Aura Navarro-Sabaté, Ramón Bartrons, Oscar Yanes, Mileidys Pérez-Alea, Eva Muñoz-Couselo, Vicenç Garcia-Patos, Jua

A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy

缓慢增殖的LGR5肿瘤细胞群介导基底细胞癌治疗后的复发

Adriana Sánchez-Danés ,Jean-Christophe Larsimont ,Mélanie Liagre ,Eva Muñoz-Couselo ,Gaëlle Lapouge ,Audrey Brisebarre ,Christine Dubois ,Mariano Suppa ,Vijayakumar Sukumaran ,Véronique Del Marmol ,Josep Tabernero ,Cédric Blanpain

Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies

USP28介导的BRAF降解丧失会导致对RAF癌症疗法的耐药性

Azad Saei ,Marta Palafox ,Touati Benoukraf ,Nishi Kumari ,Patrick William Jaynes ,Prasanna Vasudevan Iyengar ,Eva Muñoz-Couselo ,Paolo Nuciforo ,Javier Cortés ,Christopher Nötzel ,Nesaretnam Barr Kumarakulasinghe ,John Lalith Charles Richard ,Zul Fazreen Bin Adam Isa ,Brendan Pang ,Marta Guzman ,Zhou Siqin ,Henry Yang ,Wai Leong Tam ,Violeta Serra ,Pieter Johan Adam Eichhorn