Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter
Alisertib 对 ABCB1、ABCG2 和细胞色素 P450 产生药代动力学药物相互作用的可能性微乎其微，但通过抑制 ABCC1 转运体，可作为双重活性抗性调节剂
期刊:Toxicology and Applied Pharmacology
影响因子:3.3
doi:10.1016/j.taap.2021.115823
Dimitrios Vagiannis, Yu Zhang, Youssif Budagaga, Eva Novotna, Adam Skarka, Sarah Kammerer, Jan-Heiner Küpper, Jakub Hofman
