日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial

AAV8 为 HIV 感染者提供广谱中和抗体的安全性和耐受性:第 1 阶段剂量递增试验

Joseph P Casazza, Evan M Cale, Sandeep Narpala, Galina V Yamshchikov, Emily E Coates, Cynthia S Hendel, Laura Novik, LaSonji A Holman, Alicia T Widge, Preeti Apte, Ingelise Gordon, Martin R Gaudinski, Michelle Conan-Cibotti, Bob C Lin, Martha C Nason, Olga Trofymenko, Shinyi Telscher, Sarah H Plumme

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

针对多种高传染性SARS-CoV-2变种的超强效抗体

Lingshu Wang # ,Tongqing Zhou # ,Yi Zhang ,Eun Sung Yang ,Chaim A Schramm ,Wei Shi ,Amarendra Pegu ,Olamide K Oloniniyi ,Amy R Henry ,Samuel Darko ,Sandeep R Narpala ,Christian Hatcher ,David R Martinez ,Yaroslav Tsybovsky ,Emily Phung ,Olubukola M Abiona ,Avan Antia ,Evan M Cale ,Lauren A Chang ,Misook Choe ,Kizzmekia S Corbett ,Rachel L Davis ,Anthony T DiPiazza ,Ingelise J Gordon ,Sabrina Helmold Hait ,Tandile Hermanus ,Prudence Kgagudi ,Farida Laboune ,Kwanyee Leung ,Tracy Liu ,Rosemarie D Mason ,Alexandra F Nazzari ,Laura Novik ,Sarah O'Connell ,Sijy O'Dell ,Adam S Olia ,Stephen D Schmidt ,Tyler Stephens ,Christopher D Stringham ,Chloe Adrienna Talana ,I-Ting Teng ,Danielle A Wagner ,Alicia T Widge ,Baoshan Zhang ,Mario Roederer ,Julie E Ledgerwood ,Tracy J Ruckwardt ,Martin R Gaudinski ,Penny L Moore ,Nicole A Doria-Rose ,Ralph S Baric ,Barney S Graham ,Adrian B McDermott ,Daniel C Douek ,Peter D Kwong ,John R Mascola ,Nancy J Sullivan ,John Misasi #

A diverse collection of B cells responded to HIV infection in infant BG505

婴儿BG505体内多种B细胞对HIV感染作出了反应

Cassandra Simonich,Mackenzie M Shipley,Laura Doepker,Theodore Gobillot,Meghan Garrett,Evan M Cale,Brianna Hennessy,Hannah Itell,Vrasha Chohan,Nicole Doria-Rose,Ruth Nduati,Julie Overbaugh

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

纵向分析揭示了HIV-1感染者体内三种MPER靶向中和抗体谱系的早期发育

Shelly J Krebs ,Young D Kwon ,Chaim A Schramm ,William H Law ,Gina Donofrio ,Kenneth H Zhou ,Syna Gift ,Vincent Dussupt ,Ivelin S Georgiev ,Sebastian Schätzle ,Jonathan R McDaniel ,Yen-Ting Lai ,Mallika Sastry ,Baoshan Zhang ,Marissa C Jarosinski ,Amy Ransier ,Agnes L Chenine ,Mangaiarkarasi Asokan ,Robert T Bailer ,Meera Bose ,Alberto Cagigi ,Evan M Cale ,Gwo-Yu Chuang ,Samuel Darko ,Jefferson I Driscoll ,Aliaksandr Druz ,Jason Gorman ,Farida Laboune ,Mark K Louder ,Krisha McKee ,Letzibeth Mendez ,M Anthony Moody ,Anne Marie O'Sullivan ,Christopher Owen ,Dongjun Peng ,Reda Rawi ,Eric Sanders-Buell ,Chen-Hsiang Shen ,Andrea R Shiakolas ,Tyler Stephens ,Yaroslav Tsybovsky ,Courtney Tucker ,Raffaello Verardi ,Keyun Wang ,Jing Zhou ,Tongqing Zhou ,George Georgiou ,S Munir Alam ,Barton F Haynes ,Morgane Rolland ,Gary R Matyas ,Victoria R Polonis ,Adrian B McDermott ,Daniel C Douek ,Lawrence Shapiro ,Sodsai Tovanabutra ,Nelson L Michael ,John R Mascola ,Merlin L Robb ,Peter D Kwong ,Nicole A Doria-Rose

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

病毒样颗粒识别缺乏突出环的 HIV V1V2 顶端结合中和抗体

Evan M Cale, Jason Gorman, Nathan A Radakovich, Ema T Crooks, Keiko Osawa, Tommy Tong, Jiaqi Li, Raju Nagarajan, Gabriel Ozorowski, David R Ambrozak, Mangai Asokan, Robert T Bailer, Anthony K Bennici, Xuejun Chen, Nicole A Doria-Rose, Aliaksandr Druz, Yu Feng, M Gordon Joyce, Mark K Louder, Sijy O'D

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

用合成糖肽模拟 HIV 广谱中和抗体表位

S Munir Alam, Baptiste Aussedat, Yusuf Vohra, R Ryan Meyerhoff, Evan M Cale, William E Walkowicz, Nathan A Radakovich, Kara Anasti, Lawrence Armand, Robert Parks, Laura Sutherland, Richard Scearce, M Gordon Joyce, Marie Pancera, Aliaksandr Druz, Ivelin S Georgiev, Tarra Von Holle, Amanda Eaton, Chri

Epitope-specific CD8+ T lymphocytes cross-recognize mutant simian immunodeficiency virus (SIV) sequences but fail to contain very early evolution and eventual fixation of epitope escape mutations during SIV infection

表位特异性 CD8+ T 淋巴细胞交叉识别突变的猿猴免疫缺陷病毒 (SIV) 序列,但无法遏制 SIV 感染期间表位逃逸突变的早期进化和最终固定

Evan M Cale, Peter Hraber, Elena E Giorgi, Will Fischer, Tanmoy Bhattacharya, Thomas Leitner, Wendy W Yeh, Cheryl Gleasner, Lance D Green, Cliff S Han, Bette Korber, Norman L Letvin

Mutations in a dominant Nef epitope of simian immunodeficiency virus diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding

猿猴免疫缺陷病毒主要 Nef 表位的突变会降低 TCR:表位肽亲和力,但不会降低表位肽:MHC I 类结合力

Evan M Cale, Heidi S Bazick, Tony A Rianprakaisang, S Munir Alam, Norman L Letvin

Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt

丙型肝炎病毒核心与 CD4+ 和 CD8+ T 细胞上的 gC1qR 直接结合导致 Lck 和 Akt 活化受损

Zhi Qiang Yao, Audrey Eisen-Vandervelde, Stephen N Waggoner, Evan M Cale, Young S Hahn