日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Vedotin Antibody-Drug Conjugate Payload Drives Platform-Based Nonclinical Safety and Pharmacokinetic Profiles

Vedotin抗体-药物偶联物有效载荷驱动基于平台的非临床安全性和药代动力学特征分析

Neff-LaFord, Haley D; Carratt, Sarah A; Carosino, Christopher; Everds, Nancy; Cardinal, Kristen A; Duniho, Steven; Schutten, Melissa M; Frantz, Christopher; Zuch de Zafra, Christina; Harstad, Eric B

The Effects of Repeat-Dose Doxorubicin on Cardiovascular Functional Endpoints and Biomarkers in the Telemetry-Equipped Cynomolgus Monkey

重复给药阿霉素对配备遥测装置的食蟹猴心血管功能终点和生物标志物的影响

Engwall, Michael J; Everds, Nancy; Turk, James R; Vargas, Hugo M

Biological Characterization of a Stable Effector Functionless (SEFL) Monoclonal Antibody Scaffold in Vitro

稳定的效应子无功能 (SEFL) 单克隆抗体支架的体外生物学特性

Ling Liu, Frederick W Jacobsen, Nancy Everds, Yao Zhuang, Yan Bin Yu, Nianyu Li, Darcey Clark, Mai Phuong Nguyen, Madeline Fort, Padma Narayanan, Kei Kim, Riki Stevenson, Linda Narhi, Kannan Gunasekaran, Jeanine L Bussiere

Is It Adverse, Nonadverse, Adaptive, or Artifact?

它是有害的、非有害的、适应性的还是人为的?

Pandiri, Arun R; Kerlin, Roy L; Mann, Peter C; Everds, Nancy E; Sharma, Alok K; Myers, L Peyton; Steinbach, Thomas J

Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors

氧代吡啶并[2,3-d]嘧啶类化合物作为共价L858R/T790M突变选择性表皮生长因子受体(EGFR)抑制剂

Wurz, Ryan P; Pettus, Liping H; Ashton, Kate; Brown, James; Chen, Jian Jeffrey; Herberich, Brad; Hong, Fang-Tsao; Hu-Harrington, Essa; Nguyen, Tom; St Jean, David J Jr; Tadesse, Seifu; Bauer, David; Kubryk, Michele; Zhan, Jinghui; Cooke, Keegan; Mitchell, Petia; Andrews, Kristin L; Hsieh, Faye; Hickman, Dean; Kalyanaraman, Nataraj; Wu, Tian; Reid, Darren L; Lobenhofer, Edward K; Andrews, Dina A; Everds, Nancy; Guzman, Roberto; Parsons, Andrew T; Hedley, Simon J; Tedrow, Jason; Thiel, Oliver R; Potter, Matthew; Radinsky, Robert; Beltran, Pedro J; Tasker, Andrew S

Serum perfluorooctanoic acid (PFOA) concentrations in normal and hyperlipidemic female hamsters dosed orally with ammonium perfluorooctanoate (APFO) for up to 30 days.

正常和高脂血症雌性仓鼠口服全氟辛酸铵 (APFO) 长达 30 天后,血清中全氟辛酸 (PFOA) 浓度的变化。

Everds Nancy E, Kennedy Gerald L

Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in Sprague-Dawley rats

临床前安全性研究中常用的操作程序对Sprague-Dawley大鼠的肝脏基因表达变化极小。

He, Yudong D; Karbowski, Christine M; Werner, Jon; Everds, Nancy; Di Palma, Chris; Chen, Yuan; Higgins-Garn, Marnie; Tran, Sandra; Afshari, Cynthia A; Hamadeh, Hisham K

A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity

一种用于基因表达分析的新型统计算法有助于区分孕烷 X 受体依赖性和独立的毒性机制

M Ann Mongan, Robert T Dunn, Steven Vonderfecht, Nancy Everds, Guang Chen, Cheng Su, Marnie Higgins-Garn, Yuan Chen, Cynthia A Afshari, Toni L Williamson, Linda Carlock, Christopher Dipalma, Suzanne Moss, Jeanine Bussiere, Charles Qualls, Yudong D He, Hisham K Hamadeh

Molecular characterization of thyroid toxicity: anchoring gene expression profiles to biochemical and pathologic end points

甲状腺毒性的分子特征:将基因表达谱与生化和病理终点联系起来

Glatt, Christine M; Ouyang, Ming; Welsh, William; Green, John W; Connor, John O; Frame, Steven R; Everds, Nancy E; Poindexter, Greg; Snajdr, Suzanne; Delker, Don A