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Properties of Acute Activation and Inhibition of the β3 Homomeric GABA(A) Receptor Mediated by Protonation of Conserved Histidine Residues

β3同源GABA(A)受体急性激活和抑制的特性，由保守组氨酸残基的质子化介导

Pierce, Spencer R; Germann, Allison L; Zhou, Yu; Menon, Saumith L; Gu, Xinghan; Lingle, Christopher J; Evers, Alex S; Steinbach, Joe Henry; Akk, Gustav

信号转导

发表日期：2025

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Direct measurements of neurosteroid binding to specific sites on GABA(A) receptors

直接测量神经甾体与GABA(A)受体特定位点的结合情况

期刊:British Journal of Pharmacology

影响因子:7.7

doi:10.1111/bph.16490

Chintala, Satyanarayana M; Tateiwa, Hiroki; Qian, Mingxing; Xu, Yuanjian; Amtashar, Fatima; Chen, Zi-Wei; Kirkpatrick, Charles C; Bracamontes, John; Germann, Allison L; Akk, Gustav; Covey, Douglas F; Evers, Alex S

信号转导

发表日期：2024

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Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABA(A) receptors

合成和评价光亲和标记试剂，用于鉴定硫酸神经甾体在NMDA和GABA(A)受体上的结合位点

期刊:RSC Advances

影响因子:4.6

doi:10.1039/d4ra07074g

Qian, Mingxing; Xu, Yuanjian; Shu, Hong-Jin; Chen, Zi-Wei; Wang, Lei; Zorumski, Charles F; Evers, Alex S; Mennerick, Steven; Covey, Douglas F

信号转导

发表日期：2024

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Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay

斑马鱼幼体实验中低效和高效GABA能神经活性类固醇行为效应的比较

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.3c00836

Germann, Allison L; Xu, Yuanjian; Covey, Douglas F; Evers, Alex S; Akk, Gustav

发表日期：2024

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Stereospecific Properties and Intracellular Transport of Novel Intrinsically Fluorescent Neurosteroids.

新型固有荧光神经甾体的立体特异性及细胞内转运

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.4c00571

Akkerman Vibeke, Reinholdt Peter, Schnoor-Madsen Rasmus, Lauritsen Line, Bader Jad, Qian Minxing, Xu Yuanjiang, Akk Gustav, Scheidt Holger A, MÃ¼ller Peter, Covey Douglas F, Evers Alex S, Kongsted Jacob, WÃ¼stner Daniel

Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor

增强神经活性类固醇对人α1β3γ2L γ-氨基丁酸A型受体的抑制作用

期刊:Molecular Pharmacology

影响因子:3

doi:10.1124/molpharm.124.000960

Pierce, Spencer R; Germann, Allison L; Covey, Douglas F; Evers, Alex S; Steinbach, Joe Henry; Akk, Gustav

Neurosteroids and their potential as a safer class of general anesthetics

神经甾体及其作为更安全的一类全身麻醉剂的潜力

期刊:Journal of Anesthesia

影响因子:2.7

doi:10.1007/s00540-023-03291-4

Tateiwa, Hiroki; Evers, Alex S

发表日期：2024

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Impact of perioperative organ injury on morbidity and mortality in 28 million surgical patients

围手术期器官损伤对2800万手术患者发病率和死亡率的影响

A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity.

电压传感器结构域中的丙泊酚结合位点介导 HCN1 通道活性的抑制

New directions in neurosteroid therapeutics in neuropsychiatry

神经精神病学中神经甾体疗法的新方向

Properties of Acute Activation and Inhibition of the β3 Homomeric GABA(A) Receptor Mediated by Protonation of Conserved Histidine Residues

β3同源GABA(A)受体急性激活和抑制的特性，由保守组氨酸残基的质子化介导

Direct measurements of neurosteroid binding to specific sites on GABA(A) receptors

直接测量神经甾体与GABA(A)受体特定位点的结合情况

Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABA(A) receptors

合成和评价光亲和标记试剂，用于鉴定硫酸神经甾体在NMDA和GABA(A)受体上的结合位点

Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay

斑马鱼幼体实验中低效和高效GABA能神经活性类固醇行为效应的比较

Stereospecific Properties and Intracellular Transport of Novel Intrinsically Fluorescent Neurosteroids.

新型固有荧光神经甾体的立体特异性及细胞内转运

Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor

增强神经活性类固醇对人α1β3γ2L γ-氨基丁酸A型受体的抑制作用

Neurosteroids and their potential as a safer class of general anesthetics

神经甾体及其作为更安全的一类全身麻醉剂的潜力