日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

In vivo site-specific engineering to reprogram T cells

利用体内位点特异性工程技术重编程T细胞

Nyberg, William A; Bernard, Pierre-Louis; Ngo, Wayne; Wang, Charlotte H; Ark, Jonathan; Rothrock, Allison; Borgo, Gina M; Kimmerly, Gabriella R; Jung, Jae Hyung; Allain, Vincent; Hamilton, Jennifer R; Baldwin, Alisha; Stickels, Robert; Wyman, Sarah; Khan, Safwaan H; Lang, Shanshan; Marsh, Donna; Almudhfar, Niran; Novick, Catherine; Mortazavi, Yasaman; Zhang, Shimin; AbdElwakil, Mahmoud M; Sandoval, Luis R; Hwang, Sidney; Chu, Simon N; Jung, Hyuncheol; Liu, Chang; Sharma, Devesh; McCreary, Travis; Li, Zhongmei; Satpathy, Ansuman T; Carnevale, Julia; Rutishauser, Rachel L; Cromer, M Kyle; Roybal, Kole T; Dodgson, Stacie E; Doudna, Jennifer A; Asokan, Aravind; Eyquem, Justin

T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T cells

T细胞衔接器通过克隆替代和IL2驱动的CD8 T细胞效应分化来控制实体瘤

Obenaus, Matthias; Poupault, Clara L; McGinnis, Christopher S; Prange, Céline; Jiang, Hua; Su, Leon L; Chen, Xiaojing; Miao, Zhuang; Muldoon, Joseph J; Yao, Winnie; Waghray, Deepa; Sun, Qinli; Eyquem, Justin; Hernández-López, Rogelio A; Satpathy, Ansuman T; Sage, Julien; Garcia, K Christopher

SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci

SEED-Selection技术能够高效富集在多个位点编辑过的原代T细胞。

Chang, Christopher R; Vykunta, Vivasvan S; Lee, Jae Hyun J; Li, Ke; Kochendoerfer, Clara; Muldoon, Joseph J; Wang, Charlotte H; Mazumder, Thomas; Sun, Yang; Goodman, Daniel B; Nyberg, William A; Liu, Chang; Allain, Vincent; Rothrock, Allison; Ye, Chun J; Marson, Alexander; Shy, Brian R; Eyquem, Justin

Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells

通过微流控涡旋脱落实现可扩展的细胞内递送,增强嵌合抗原受体T细胞的功能

Sytsma, Brandon J; Allain, Vincent; Bourke, Struan; Faizee, Fairuz; Fathi, Mohsen; Ferreira, Leonardo M R; Brewer, W Jared; Li, Lian; Pan, Fong L; Rothrock, Allison G; Nyberg, William A; Li, Zhongmei; Wilson, Leah H; Berdeaux, Rebecca; Eyquem, Justin; Pawell, Ryan S

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells

病毒样颗粒能够对原代人髓系细胞进行靶向基因工程和混合 CRISPR 筛选。

Jung, Hyuncheol; Devant, Pascal; Ching, Carter; Ota, Mineto; Hamilton, Jennifer; Steinhart, Zachary; Ngo, Wayne; Sandoval, Luis; Jung, Jae Hyung; Xu, Da; An, Meirui; Urs, Esha; Chen, Peixin Amy; Allain, Vincent; Tada, Takuya; Nuñez, James K; Landau, Nathaniel R; Liu, David R; Eyquem, Justin; Doudna, Jennifer A; Marson, Alexander; Carnevale, Julia

Decoding Peripheral Tolerance: TCR Rules for pTreg differentiation in the Gut

解码外周耐受性:肠道中 pTreg 分化的 TCR 规则

Chi, Xinxin; Wang, Charlotte H; Parisotto, Yollanda Franco; Nyberg, William A; Cabric, Vanja; Gelineau, Adelaide; Cao, Yi; Owen, David L; Ambjörnsson, Jonas; Mathis, Diane; Eyquem, Justin; Brown, Chrysothemis C; Benoist, Christophe

Bicistronic CAR T-cells Against CD70 & Active Integrin β2 Overcome Antigen Heterogeneity and Preserve Safety in Acute Myeloid Leukemia

针对 CD70 和活性整合素 β2 的双顺反子 CAR T 细胞可克服抗原异质性并保持急性髓系白血病的安全性

Kang, Amrik S; Johnson, Haley; Lei, Nicole; Wong, Jeremiah; Razi, Nabeel; Izgutdina, Adila; Kasap, Corynn; Chilakapati, Nikhil; Rivera, Jose; Phojanakong, Paul; Serrano, Juan Antonio Camara; Salangsang, Fernando; Steri, Veronica; Logan, Aaron C; Eyquem, Justin; Huang, Benjamin J; Wiita, Arun P

Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro

可编程微粒重塑CAR信号通路,从而在体外实现人T细胞的超生理扩增

Zeng, Qinghe; Flemming, Landon; Chen, Yuanzhou; Mazumder, Thomas; Hammerlindl, Heinz; Allen, Greg M; Almeida, Ricardo; Williams, Jasper Z; Hernández-López, Rogelio A; Eyquem, Justin; Ye, Chun J; Lim, Wendell A; Tang, Qizhi; Desai, Tejal A; Huang, Xiao

Site-specific genome engineering of primary human natural killer cells for programmable anti-tumor function

利用位点特异性基因组工程改造原代人类自然杀伤细胞,使其具备可编程的抗肿瘤功能

Allain, Vincent; Rothrock, Allison G; Bernard, Pierre-Louis; Nyberg, William A; Talbot, Alexis; Muldoon, Joseph J; Chung, Jing-Yi; To, Angela; Chang, Christopher R; Kimmerly, Gabriella R; Liu, Chang; Tsao, Tasha; Mortazavi, Yasaman; Seo, Jin; Li, Zhongmei; Shemesh, Avishai; Schmidt, Ralf; Ward, Carl C; Marson, Alexander; Lanier, Lewis L; Aguilar, Oscar A; Eyquem, Justin

Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy

对 A20 基因中的单个错义突变进行碱基编辑可增强 CAR-T 细胞的疗效

Blaisdell, Adam; Bachl, Stefanie; Sandoval, Luis R; Ching, Carter; Bowman, Christopher J; Kale, Nupura; Prabandham, Manu; Diolaiti, Morgan; Havig, Claire; Advincula, Rommel; Lenci, Nika; Li, Zhongmei; Yamashita, Emily; Wang, Charlotte H; Zhang, Shimin; Liu, Qi; Achacoso, Philip; Stibor, Dorothea; Øynebråten, Inger; Seo, Jin; Ashworth, Alan; Marson, Alexander; Ye, Chun Jimmie; Malynn, Barbara A; Eyquem, Justin; Carnevale, Julia; Ma, Averil