The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons
接触系统会导致低血压,但不会导致致命性菌血症中的弥散性血管内凝血。在狒狒体内使用单克隆抗因子XII抗体阻断接触激活。
期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI116201
Pixley, R A; De La Cadena, R; Page, J D; Kaufman, N; Wyshock, E G; Chang, A; Taylor, F B Jr; Colman, R W