PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor

PI3K/mTOR 通路抑制剂可增强慢性粒细胞白血病干细胞对尼洛替尼的敏感性，并在干细胞因子存在的情况下恢复祖细胞对尼洛替尼的反应