日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AKAP2 is required for assembly of cytoskeletal signaling complexes that promote growth and metastasis of triple-negative breast cancer

AKAP2是细胞骨架信号复合物组装所必需的,这些复合物促进三阴性乳腺癌的生长和转移。

Rosenthal, Kacey J; Felix-Sanchez, Pamela; Forbush, Katherine; Rhoads, Nicole; Kang, Mingu; Vicente, Juan Jesus; Smith, F Donelson; Wordeman, Linda; Ong, Shao-En; Cheung, Kevin J; Scott, John D

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

VISTA 采用 pH 选择性抗体 SNS-101 进行检查点抑制,该抗体具有优化的安全性和药代动力学特征,可增强 PD-1 反应。

Thomas Thisted ,F Donelson Smith ,Arnab Mukherjee ,Yuliya Kleschenko ,Feng Feng ,Zhi-Gang Jiang ,Timothy Eitas ,Kanam Malhotra ,Zuzana Biesova ,Adejumoke Onumajuru ,Faith Finley ,Anokhi Cifuentes ,Guolin Zhang ,Gaëlle H Martin ,Yoshiko Takeuchi ,Kader Thiam ,Robert D Schreiber ,Edward H van der Horst

Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma

BAG2 募集至 DNAJ-PKAc 支架可促进纤维板层癌细胞存活并增强其对药物诱导凋亡的抵抗力。

Lauer, Sophia M; Omar, Mitchell H; Golkowski, Martin G; Kenerson, Heidi L; Lee, Kyung-Soon; Pascual, Bryan C; Lim, Huat C; Forbush, Katherine; Smith, F Donelson; Gordan, John D; Ong, Shao-En; Yeung, Raymond S; Scott, John D

Conditionally Active, pH-Sensitive Immunoregulatory Antibodies Targeting VISTA and CTLA-4 Lead an Emerging Class of Cancer Therapeutics

靶向VISTA和CTLA-4的条件性活性、pH敏感型免疫调节抗体引领了一类新兴的癌症治疗药物

Smith, F Donelson; Pierce, Robert H; Thisted, Thomas; van der Horst, Edward H

Mislocalization of protein kinase A drives pathology in Cushing's syndrome

蛋白激酶A的错误定位是库欣综合征病理发生的主要原因。

Mitchell H Omar ,Dominic P Byrne ,Kiana N Jones ,Tyler M Lakey ,Kerrie B Collins ,Kyung-Soon Lee ,Leonard A Daly ,Katherine A Forbush ,Ho-Tak Lau ,Martin Golkowski ,G Stanley McKnight ,David T Breault ,Anne-Marie Lefrançois-Martinez ,Antoine Martinez ,Claire E Eyers ,Geoffrey S Baird ,Shao-En Ong ,F Donelson Smith ,Patrick A Eyers ,John D Scott

Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities

纤维板层癌中异常增强子活性的热点区域揭示了候选致癌通路和治疗弱点

Timothy A Dinh,Ramja Sritharan,F Donelson Smith,Adam B Francisco,Rosanna K Ma,Rodica P Bunaciu,Matt Kanke,Charles G Danko,Andrew P Massa,John D Scott,Praveen Sethupathy

A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface

基于 A 激酶锚定蛋白 1 (dAKAP1) 的信号复合物协调线粒体表面的局部蛋白质合成

Laura Gabrovsek, Kerrie B Collins, Stacey Aggarwal, Lauren M Saunders, Ho-Tak Lau, Danny Suh, Yasemin Sancak, Cole Trapnell, Shao-En Ong, F Donelson Smith, John D Scott

Subcellular drug targeting illuminates local kinase action

亚细胞药物靶向阐明局部激酶作用

Paula J Bucko, Chloe K Lombard #, Lindsay Rathbun #, Irvin Garcia, Akansha Bhat, Linda Wordeman, F Donelson Smith, Dustin J Maly, Heidi Hehnly, John D Scott

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

DNAJ-PKAc融合蛋白获得的支架功能促进了纤维板层癌的致癌信号传导。

Rigney E Turnham # ,F Donelson Smith # ,Heidi L Kenerson # ,Mitchell H Omar # ,Martin Golkowski ,Irvin Garcia ,Renay Bauer ,Ho-Tak Lau ,Kevin M Sullivan ,Lorene K Langeberg ,Shao-En Ong ,Kimberly J Riehle ,Raymond S Yeung ,John D Scott

Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility

线粒体外膜上 dAKAP1-蛋白激酶 A 信号岛的消耗会改变乳腺癌细胞的代谢和运动能力

Stacey Aggarwal, Laura Gabrovsek, Lorene K Langeberg, Martin Golkowski, Shao-En Ong, F Donelson Smith, John D Scott