日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ

巨噬细胞通过TLR诱导的IL-12和IFN-γ介导的清除作用,将志贺氏菌从肠道上皮细胞微环境中清除。

Kevin D Eislmayr ,Charlotte A Nichols ,Fitty L Liu ,Sudyut Yuvaraj ,Janet Peace Babirye ,Justin L Roncaioli ,Jenna Vickery ,Gregory M Barton ,Cammie F Lesser ,Russell E Vance

A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control

对免疫细胞中核受体的泛家族筛选揭示了配体依赖性炎症小体调控

Yutao Wang ,Yanbo Zhang ,Kyungsub Kim ,Jichang Han ,Daniel Okin ,Zhaozhao Jiang ,Liang Yang ,Arum Subramaniam ,Terry K Means ,Frank O Nestlé ,Katherine A Fitzgerald ,Gwendalyn J Randolph ,Cammie F Lesser ,Jonathan C Kagan ,Diane Mathis ,Christophe Benoist

Gut bacterial type III secretion systems aggravate colitis in mice and serve as biomarkers of Crohn's disease

肠道细菌 III 型分泌系统加重小鼠结肠炎并作为克罗恩病的生物标志物

Jun Xu, Peijie Li, Zhenye Li, Sheng Liu, Huating Guo, Cammie F Lesser, Jia Ke, Wenjing Zhao, Xiangyu Mou

In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli

工程共生微生物原位沉积纳米抗体可促进肠出血性大肠杆菌小鼠模型中的存活

Rajkamal Srivastava, Coral González-Prieto, Jason P Lynch, Michele E Muscolo, Catherine Y Lin, Markus A Brown, Luisa Lemos, Anishma Shrestha, Marcia S Osburne, John M Leong, Cammie F Lesser

In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli

工程共生微生物原位沉积纳米抗体可促进肠出血性大肠杆菌小鼠模型中的存活

Rajkamal Srivastava, Coral González-Prieto, Jason P Lynch, Michele Muscolo, Catherine Y Lin, Markus A Brown, Luisa Lemos, Anishma Shrestha, Marcia S Osburne, John M Leong, Cammie F Lesser

Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut

经基因工程改造的大肠杆菌用于在肠道内原位分泌治疗性纳米抗体

Jason P Lynch ,Coral González-Prieto ,Analise Z Reeves ,Sena Bae ,Urmila Powale ,Neha P Godbole ,Jacqueline M Tremblay ,Florian I Schmidt ,Hidde L Ploegh ,Vikram Kansra ,Jonathan N Glickman ,John M Leong ,Charles B Shoemaker ,Wendy S Garrett ,Cammie F Lesser

A hierarchy of cell death pathways confers layered resistance to shigellosis in mice

细胞死亡途径的层次结构赋予小鼠对志贺氏菌病的分层抵抗力

Justin L Roncaioli, Janet Peace Babirye, Roberto A Chavez, Fitty L Liu, Elizabeth A Turcotte, Angus Y Lee, Cammie F Lesser, Russell E Vance

Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation

志贺氏菌IpaH9.8限制胞浆内细菌释放GBP1依赖的LPS,从而抑制caspase-4活化

Lisa Goers, Kyungsub Kim, Teagan C Stedman, Patrick J Canning, Xiangyu Mou, Nadja Heinz Ernst, Jörn Coers, Cammie F Lesser

A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling

一类保守的细菌毒力因子通过阻断钙信号传导来抑制干扰素反应。

Noémie Alphonse ,Joseph J Wanford ,Andrew A Voak ,Jack Gay ,Shayla Venkhaya ,Owen Burroughs ,Sanjana Mathew ,Truelian Lee ,Sasha L Evans ,Weiting Zhao ,Kyle Frowde ,Abrar Alrehaili ,Ruth E Dickenson ,Mads Munk ,Svetlana Panina ,Ishraque F Mahmood ,Miriam Llorian ,Megan L Stanifer ,Steeve Boulant ,Martin W Berchtold ,Julien R C Bergeron ,Andreas Wack ,Cammie F Lesser ,Charlotte Odendall

The Shigella Spp. Type III Effector Protein OspB Is a Cysteine Protease

志贺氏菌属 III 型效应蛋白 OspB 是一种半胱氨酸蛋白酶

Thomas E Wood ,Kathleen A Westervelt ,Jessica M Yoon ,Heather D Eshleman ,Roie Levy ,Henry Burnes ,Daniel J Slade ,Cammie F Lesser ,Marcia B Goldberg