Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
柠檬酸抑制ACOD1(IRG1)催化,降低干扰素反应和氧化应激,并调节炎症和细胞代谢。
期刊:Nature Metabolism
影响因子:18.9
doi:10.1038/s42255-022-00577-x
F Chen ,W A M Elgaher # ,M Winterhoff # ,K Büssow # ,F H Waqas ,E Graner ,Y Pires-Afonso ,L Casares Perez ,L de la Vega ,N Sahini ,L Czichon ,W Zobl ,T Zillinger ,M Shehata ,S Pleschka ,H Bähre ,C Falk ,A Michelucci ,S Schuchardt ,W Blankenfeldt ,A K H Hirsch ,F Pessler