日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interaction of Cytochrome P450 3A4 with Fatty Acid Binding Protein 1 and Relevance to Drug Metabolism

细胞色素P450 3A4与脂肪酸结合蛋白1的相互作用及其与药物代谢的相关性

McCarty, Kevin D; Proffett, Destiny L D; Guengerich, F Peter

A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1.

从胆固醇到性类固醇生物合成的旁路途径绕过了 CYP17A1。

Zhu Ziqi, Chung Yoon-Mi, Alyamani Mohammad, Dai Yijing, McCarty Kevin D, Roberts Evan, Sinha Sunita, Li Jianneng, Li Xiuxiu, Gad Emad M, Zhou Zhiqun, Shi Jinyuan, Burgess Robert A, Hargrove Tatiana Y, Lepesheva Galina I, Guengerich F Peter, Auchus Richard J, Sharifi Nima

Cytochrome P450(BM-3) and P450 11A1 retain Compound I (FeO(3+)) chemistry with electrophilic substrates poised for Compound 0 (Fe(3+)O(2)(-)) reactions

细胞色素 P450(BM-3) 和 P450 11A1 保留了化合物 I (FeO(3+)) 的化学性质,而亲电底物则准备发生化合物 0 (Fe(3+)O(2)(-)) 反应。

McCarty, Kevin D; Tateishi, Yasuhiro; Guengerich, F Peter

Mass Spectral Analysis of Sterols and Other Steroids in Different Ionization Modes: Sensitivity and Oxidation Artifacts

不同电离模式下甾醇和其他类固醇的质谱分析:灵敏度和氧化伪影

McCarty, Kevin D; Guengerich, F Peter

A synthesis of 1β-hydroxytestosterone, a metabolite of xenobiotic human cytochrome P450 enzymes, beginning with a borylation of boldione

以硼二酮的硼化反应为起始原料,合成1β-羟基睾酮,1β-羟基睾酮是异源生物人细胞色素P450酶的代谢产物。

Elizondo, Anna I; McCarty, Kevin D; Arman, Hadi D; Guengerich, F Peter; Yoshimoto, Francis K

Revisiting Africa's Stroke Obstacles and Services (SOS)

重新审视非洲中风障碍和服务(SOS)

Roushdy, Tamer; Elbassiouny, Ahmed; Kesraoui, Selma; Temgoua, Michael; Nono, Kiatoko Ponte; Melkamu, Selam Kifelew; Sadiq, Eitzaz; Francis, Patty; Omar, Oday F; Peter, Waweru; Gopaul, Urvashy; Belahsen, Mohammed Faouzi; Ugbem, Lukpata Philip; Ben-Adji, Djibrilla; Woodcock, Noëmie; Mohamed, Muhyadin Hassan; Matuja, Sarah; Mhiri, Chokri; Saylor, Deanna; Maged, Mohamed; Shokri, Hossam; Nahas, Nevine El

Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism

人类细胞色素P450酶在药物代谢中的作用

Guengerich, F Peter

Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation

氧-18标记揭示了细胞色素P450 51甾醇14α-去甲基化反应最后一步的混合Fe-O机制

McCarty, Kevin D; Tateishi, Yasuhiro; Hargrove, Tatiana Y; Lepesheva, Galina I; Guengerich, F Peter

Roles of Ferric Peroxide Anion Intermediates (Fe(3+)O(2) (-), Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model

过氧化铁阴离子中间体(Fe(3+)O(2) (-),化合物 O)在细胞色素 P450 19A1 甾体芳构化和细胞色素 P450 2B4 开环甾体氧化模型中的作用

Tateishi, Yasuhiro; McCarty, Kevin D; Martin, Martha V; Yoshimoto, Francis K; Guengerich, F Peter

Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4

氧-18标记揭示了细胞色素P450 2B4催化醛氧化脱甲酰化反应中的过氧化铁(化合物0)机制

Tateishi, Yasuhiro; McCarty, Kevin D; Martin, Martha V; Guengerich, F Peter