F Susan相关文献与解析，生知库 | 链接生命科学的每一步

Boldison, Joanne; Leete, Pia; Robinson, Emma J; Powell, Wendy; Davies, Joanne; McMullan, Conor; Walker, Sophie L; Morgan, Noel G; Hanna, Stephanie J; Wong, F Susan

B细胞

代谢

CXCR3

Is the NOD mouse a good model for type 1 diabetes?

NOD小鼠是1型糖尿病的良好模型吗？

期刊:Diabetologia

影响因子:10.2

doi:10.1007/s00125-025-06579-0

Wong, F Susan; Pearson, James A; Wen, Li

Blockade of glucagon receptor induces Î±-cell hypersecretion by hyperaminoacidemia in mice.

阻断胰高血糖素受体可诱导小鼠高氨基酸血症引起的α细胞过度分泌

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-57786-7

Jia Jianxin, Bai Xuanxuan, Kang Qi, Jiang Fuquan, Wong F Susan, Jin Quanwen, Li Mingyu

细胞生物学

发表日期：2025

文献求助收藏

IL17-deficient NOD mice are protected from autoimmune diabetes due to decreased antigen presentation and T cell activation

IL17缺陷型NOD小鼠由于抗原呈递和T细胞活化的降低，免受自身免疫性糖尿病的侵害。

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2025.1728313

Pearson, James A; Li, Yangyang; Huang, Juan; Peng, Jian; Wong, F Susan; Wen, Li

Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice

B6小鼠胰岛β细胞中PDGFRα的缺乏会促进β细胞凋亡并扰乱葡萄糖代谢。

期刊:Frontiers in Endocrinology

影响因子:4.6

doi:10.3389/fendo.2025.1630979

Zhang, Luyao; Xing, Yanpeng; Wang, Pai; Gu, Jianlei; Peng, Jian; Huang, Juan; Pearson, James Alexander; Hu, Youjia; Zhao, Hongyu; Wong, F Susan; Wen, Li

Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis

细胞 Tlr9 缺乏会促进炎症和肠道菌群失调，从而导致肥胖

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-48611-8

Pai Wang #, Xin Yang #, Luyao Zhang, Sha Sha, Juan Huang, Jian Peng, Jianlei Gu, James Alexander Pearson, Youjia Hu, Hongyu Zhao, F Susan Wong, Quan Wang, Li Wen

Immunology/Inflammation

发表日期：2024

文献求助收藏

Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes

调节性 CD4+ T 细胞重定向至致病性 CD8+ T 细胞，保护 NOD 小鼠免于患上自身免疫性糖尿病

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2024.1463971

Dimitri Kakabadse, Dawei Chen, Sigal Fishman, Hadas Weinstein-Marom, Joanne Davies, Li Wen, Gideon Gross, F Susan Wong

TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model

TLR5 缺陷控制自身免疫性糖尿病易感模型中的树突状细胞亚群发育

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2024.1333967

James Alexander Pearson, Youjia Hu, Jian Peng, F Susan Wong, Li Wen

Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes

胰岛素降解酶调节小鼠 1 型糖尿病中胰岛素引导的细胞自身免疫

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2024.1474453

Marie-Andrée Bessard #, Anna Moser #, Emmanuelle Waeckel-Énée, Vivian Lindo, Abdelaziz Gdoura, Sylvaine You, F Susan Wong, Fiona Greer, Peter van Endert

Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D

来自 B 细胞特异性 TLR9 缺陷型 NOD 小鼠的肠道菌群可促进 IL-10+ Breg 细胞的生成，并预防 1 型糖尿病。

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2024.1413177

Xin Yang ，Juan Huang ，Jian Peng ，Pai Wang ，F Susan Wong ，Ruirui Wang ，Dapeng Wang ，Li Wen

CXCR3 expression on antigen-experienced B cells is systemically dysregulated in type 1 diabetes

1型糖尿病中，抗原经历B细胞上的CXCR3表达存在系统性紊乱。

Is the NOD mouse a good model for type 1 diabetes?

NOD小鼠是1型糖尿病的良好模型吗？

Blockade of glucagon receptor induces Î±-cell hypersecretion by hyperaminoacidemia in mice.

阻断胰高血糖素受体可诱导小鼠高氨基酸血症引起的α细胞过度分泌

IL17-deficient NOD mice are protected from autoimmune diabetes due to decreased antigen presentation and T cell activation

IL17缺陷型NOD小鼠由于抗原呈递和T细胞活化的降低，免受自身免疫性糖尿病的侵害。

Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice

B6小鼠胰岛β细胞中PDGFRα的缺乏会促进β细胞凋亡并扰乱葡萄糖代谢。

Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis

细胞 Tlr9 缺乏会促进炎症和肠道菌群失调，从而导致肥胖

Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes

调节性 CD4+ T 细胞重定向至致病性 CD8+ T 细胞，保护 NOD 小鼠免于患上自身免疫性糖尿病

TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model

TLR5 缺陷控制自身免疫性糖尿病易感模型中的树突状细胞亚群发育

Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes

胰岛素降解酶调节小鼠 1 型糖尿病中胰岛素引导的细胞自身免疫

Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D

来自 B 细胞特异性 TLR9 缺陷型 NOD 小鼠的肠道菌群可促进 IL-10+ Breg 细胞的生成，并预防 1 型糖尿病。