日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Miniaturized IL-2/anti-IL-2 immunocytokines selectively activate and support the in vivo persistence of regulatory T cells

微型化的IL-2/抗IL-2免疫细胞因子选择性地激活并支持调节性T细胞在体内的持续存在。

Fabilane, Charina S; Tomala, Jakub; Zdinak, Paul M; Chalmers, Bailey T; Stephenson, A Carson; Ariail, Emily; Teeley, Ella C; Joglekar, Alok V; Spangler, Jamie B

Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion

CD25偏向性IL-2激动剂和免疫检查点阻断剂的时间优化,即使在调节性T细胞大量扩增的情况下,也能产生协同抗癌活性。

Kilic, Irfan Baki; Weberova, Petra; VanDyke, Derek; Sirova, Milada; Kubesova, Katerina; Fabilane, Charina S; Mazhara, Vladyslav; Liu, Kathy; Behalova, Katerina; Ptacek, Bohumil; Rihova, Blanka; Spangler, Jamie B; Kovar, Marek

An engineered Treg selective immunocytokine induces sustained immune modulation in a preclinical model of hemophilia A

一种经基因工程改造的Treg选择性免疫细胞因子可在A型血友病临床前模型中诱导持续的免疫调节。

Rana, Jyoti; VanDyke, Derek; Muñoz-Melero, Maite; Fabilane, Charina S; Thirumurugan, Senthilkumar; Arisa, Sreevani; Zhou, Baohua; Spangler, Jamie B; Biswas, Moanaro

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network

通过核心变构结构网络调节IL-2免疫信号功能

Claire H Woodward ,Shahlo O Solieva ,Daniel Hwang ,Viviane S De Paula ,Charina S Fabilane ,Michael C Young ,Tony Trent ,Ella C Teeley ,Ananya Majumdar ,Jamie B Spangler ,Gregory R Bowman ,Nikolaos G Sgourakis

Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism.

瞬态聚(ADP-核糖)通过类似朊病毒的机制触发FUS缩合滞后

Liu Hongrui, Cai Yuxuan, Shi Leilei, Pillai Meenakshi, Das Nilimesh, Tarbox Haley E, Ge Yingda, Yue Kun, Yang Xingyi, Rath Piyush, Badiee Mohsen, Fabilane Charina S, Spangler Jamie B, Bedford Mark T, Myong Sua, Fried Stephen D, Ding Xinqiang, Leung Anthony K L

Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases

利用分子工程改造白细胞介素-2以增强其在自身免疫性疾病中的治疗活性

Tomasovic, Luke M; Liu, Kathy; VanDyke, Derek; Fabilane, Charina S; Spangler, Jamie B

Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity

工程化细胞因子/抗体融合蛋白可改善IL-2向促炎细胞的递送,并促进抗肿瘤活性。

Leonard, Elissa K; Tomala, Jakub; Gould, Joseph R; Leff, Michael I; Lin, Jian-Xin; Li, Peng; Porter, Mitchell J; Johansen, Eric R; Thompson, Ladaisha; Cao, Shanelle D; Hou, Shenda; Henclova, Tereza; Huliciak, Maros; Sargunas, Paul R; Fabilane, Charina S; Vaněk, Ondřej; Kovar, Marek; Schneider, Bohdan; Raimondi, Giorgio; Leonard, Warren J; Spangler, Jamie B

Cytokine/Antibody Fusion Protein Design and Evaluation.

细胞因子/抗体融合蛋白的设计与评价

Fabilane Charina S, Stephenson A Carson, Leonard Elissa K, VanDyke Derek, Spangler Jamie B

Mechanism of Lipid Binding of Human Apolipoprotein E3 by Hydrogen/Deuterium Exchange/Mass Spectrometry and Fluorescence Polarization

利用氢/氘交换/质谱和荧光偏振法研究人载脂蛋白E3的脂质结合机制

Fabilane, Charina S; Nguyen, Patricia N; Hernandez, Roy V; Nirudodhi, Sasidhar; Duong, Mai; Maier, Claudia S; Narayanaswami, Vasanthy