日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rilotumumab Resistance Acquired by Intracrine Hepatocyte Growth Factor Signaling

通过分泌肝细胞生长因子信号获得利妥昔单抗耐药性

Fabiola Cecchi, Karen Rex, Joanna Schmidt, Cathy D Vocke, Young H Lee, Sandra Burkett, Daniel Baker, Michael A Damore, Angela Coxon, Teresa L Burgess, Donald P Bottaro

Case report: Complete pathologic response with first-line immunotherapy combination in a young adult with massive liver dissemination of mismatch repair-deficient metastatic colorectal cancer: Immunological and molecular profiling

病例报告:一线免疫疗法联合治疗一名年轻成人,在错配修复缺陷型转移性结直肠癌大量肝转移后获得完全病理缓解:免疫学和分子分析

Francesca Bergamo, Silvia Dalla Santa, Fotios Loupakis, Krisida Cerma, Anna Tosi, Caterina De Grandis, Anna Dalla Pietà, Enrico Gringeri, Valentina Angerilli, Gaetano Ramondo, Alessandro Rago, Fabiola Cecchi, Stephen Benz, Umberto Cillo, Angelo Paolo Dei Tos, Vittorina Zagonel, Matteo Fassan, Antoni

Combination therapy with pazopanib and tivantinib modulates VEGF and c-MET levels in refractory advanced solid tumors

帕唑帕尼与替凡替尼联合治疗可调节难治性晚期实体肿瘤中的 VEGF 和 c-MET 水平

Shivaani Kummar, Apurva K Srivastava, Tony Navas, Fabiola Cecchi, Young H Lee, Donald P Bottaro, Sook Ryun Park, Khanh T Do, Woondong Jeong, Barry C Johnson, Andrea R Voth, Larry Rubinstein, John J Wright, Ralph E Parchment, James H Doroshow, Alice P Chen

Overcoming hypoxia-induced functional suppression of NK cells

克服缺氧引起的 NK 细胞功能抑制

Kristen Solocinski, Michelle R Padget, Kellsye P Fabian, Benjamin Wolfson, Fabiola Cecchi, Todd Hembrough, Stephen C Benz, Shahrooz Rabizadeh, Patrick Soon-Shiong, Jeffrey Schlom, James W Hodge

High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies

未分化多形性肉瘤的高通量分析确定了两个主要亚组,它们具有不同的免疫特征、临床结果和对靶向治疗的敏感性

Maud Toulmonde, Carlo Lucchesi, Stéphanie Verbeke, Amandine Crombe, Julien Adam, Damien Geneste, Vanessa Chaire, Audrey Laroche-Clary, Raul Perret, François Bertucci, Frederic Bertolo, Laurence Bianchini, Bérengère Dadone-Montaudie, Todd Hembrough, Steve Sweet, Yeoun Jin Kim, Fabiola Cecchi, Françoi

MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer

MET 激活导致对西妥昔单抗产生耐药性,并阻止头颈癌中的 HER2 和 HER3 上调

Ofra Novoplansky, Matthew Fury, Manu Prasad, Ksenia Yegodayev, Jonathan Zorea, Limor Cohen, Raphael Pelossof, Liz Cohen, Nora Katabi, Fabiola Cecchi, Ben-Zion Joshua, Aron Popovtzer, Jose Baselga, Maurizio Scaltriti, Moshe Elkabets

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

通过联合 MEK 和 SHP2 抑制靶向野生型 KRAS 扩增的胃食管癌

Gabrielle S Wong, Jin Zhou, Jie Bin Liu, Zhong Wu, Xinsen Xu, Tianxia Li, David Xu, Steven E Schumacher, Jens Puschhof, James McFarland, Charles Zou, Austin Dulak, Les Henderson, Peng Xu, Emily O'Day, Rachel Rendak, Wei-Li Liao, Fabiola Cecchi, Todd Hembrough, Sarit Schwartz, Christopher Szeto, Anil

Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for EGFR-Amplified Gastroesophageal Adenocarcinoma

针对特定人群的靶向治疗:EGFR扩增的胃食管腺癌的抗EGFR治疗

Steven B Maron, Lindsay Alpert, Heewon A Kwak, Samantha Lomnicki, Leah Chase, David Xu, Emily O'Day, Rebecca J Nagy, Richard B Lanman, Fabiola Cecchi, Todd Hembrough, Alexa Schrock, John Hart, Shu-Yuan Xiao, Namrata Setia, Daniel V T Catenacci

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS

具有 3 类 BRAF 突变的肿瘤对抑制激活的 RAS 很敏感

Zhan Yao, Rona Yaeger, Vanessa S Rodrik-Outmezguine, Anthony Tao, Neilawattie M Torres, Matthew T Chang, Matthias Drosten, Huiyong Zhao, Fabiola Cecchi, Todd Hembrough, Judith Michels, Hervé Baumert, Linde Miles, Naomi M Campbell, Elisa de Stanchina, David B Solit, Mariano Barbacid, Barry S Taylor, 

Proof of the quantitative potential of immunofluorescence by mass spectrometry

通过质谱法证明免疫荧光的定量潜力

Maria I Toki, Fabiola Cecchi, Todd Hembrough, Konstantinos N Syrigos, David L Rimm