日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective remodelling of the adipose niche in obesity and weight loss

肥胖和体重减轻中脂肪微环境的选择性重塑

Antonio M A Miranda ,Liam McAllan ,Guianfranco Mazzei ,Ivan Andrew ,Iona Davies ,Meryem Ertugrul ,Julia Kenkre ,Hiromi Kudo ,Joana Carrelha ,Bhavik Patel ,Sophie Newton ,Weihua Zhang ,Alice Pollard ,Amy Cross ,Oliver McCallion ,Mikyung Jang ,Ka Lok Choi ,Scarlett Brown ,Yasmin Rasool ,Marco Adamo ,Mohamed Elkalaawy ,Andrew Jenkinson ,Borzoueh Mohammadi ,Majid Hashemi ,Robert Goldin ,Laurence Game ,Joanna Hester ,Fadi Issa ,Dylan G Ryan ,Patricia Ortega ,Ahmed R Ahmed ,Rachel L Batterham ,John C Chambers ,Jaspal S Kooner ,Damir Baranasic ,Michela Noseda ,Tricia Tan ,William R Scott

HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model

在人源化小鼠移植模型中,HLA配型或HLA I/II类基因的CRISPR编辑可使同种异体人源调节性T细胞疗法实现植入并发挥有效功能。

Oliver McCallion #,Weijie Du #,Viktor Glaser #,Kate Milward,Sarah Short,Merve Bilici,Amy Cross,Helen Stark,Clemens Franke,Jonas Kath,Mikhail Valkov,Mingxing Yang,Leila Amini,Annette Künkele,Julia K Polansky,Michael Schmueck-Henneresse,Hans-Dieter Volk,Petra Reinke,Dimitrios L Wagner,Joanna Hester,Fadi Issa

Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants

调节性T细胞疗法与肾移植中独特的免疫调节性淋巴细胞浸润有关。

Oliver McCallion ,Amy R Cross ,Matthew O Brook ,Conor Hennessy ,Ricardo Ferreira ,Dominik Trzupek ,William R Mulley ,Sandeep Kumar ,Maria Soares ,Ian S Roberts ,Peter J Friend ,Giovanna Lombardi ,Kathryn J Wood ,Paul N Harden ,Joanna Hester ,Fadi Issa

Multiscale topology classifies cells in subcellular spatial transcriptomics

多尺度拓扑结构对亚细胞空间转录组学中的细胞进行分类

Katherine Benjamin #,Aneesha Bhandari # ,Jessica D Kepple ,Rui Qi ,Zhouchun Shang ,Yanan Xing ,Yanru An,Nannan Zhang,Yong Hou,Tanya L Crockford ,Oliver McCallion,Fadi Issa,Joanna Hester,Ulrike Tillmann,Heather A Harrington     ,Katherine R Bull

Direct correction of haemoglobin E β-thalassaemia using base editors

使用碱基编辑器直接校正血红蛋白 E β-地中海贫血

Mohsin Badat, Ayesha Ejaz, Peng Hua, Siobhan Rice, Weijiao Zhang, Lance D Hentges, Christopher A Fisher, Nicholas Denny, Ron Schwessinger, Nirmani Yasara, Noemi B A Roy, Fadi Issa, Andi Roy, Paul Telfer, Jim Hughes, Sachith Mettananda, Douglas R Higgs, James O J Davies

Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs

单细胞空间分析揭示 COVID-19 肺中未成熟中性粒细胞和 CD8 T 细胞的炎症灶

Praveen Weeratunga #, Laura Denney #, Joshua A Bull #, Emmanouela Repapi #, Martin Sergeant, Rachel Etherington, Chaitanya Vuppussetty, Gareth D H Turner, Colin Clelland, Jeongmin Woo, Amy Cross, Fadi Issa, Carlos Eduardo de Andrea, Ignacio Melero Bermejo, David Sims, Simon McGowan, Yasemin-Xiomara

Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism

赫曼斯基-普德拉克综合征1型由于免疫代谢失调导致抗菌免疫受损和炎症。

Athena Cavounidis ,Sumeet Pandey ,Melania Capitani ,Matthias Friedrich ,Amy Cross ,Lisa Gartner ,Dominik Aschenbrenner ,Seunghee Kim-Schulze ,Ying Ka Lam ,Georgina Berridge ,Dermot P B McGovern ,Benedikt Kessler ,Roman Fischer ,Paul Klenerman ,Joanna Hester ,Fadi Issa ,Esther A Torres ,Fiona Powrie ,Bernadette R Gochuico ,William A Gahl ,Louis Cohen # ,Holm H Uhlig #

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

经基因工程改造的人类细胞因子/抗体融合蛋白可扩增调节性T细胞,并赋予自身免疫性疾病保护作用。

Derek VanDyke ,Marcos Iglesias ,Jakub Tomala ,Arabella Young ,Jennifer Smith ,Joseph A Perry ,Edward Gebara ,Amy R Cross ,Laurene S Cheung ,Arbor G Dykema ,Brian T Orcutt-Jahns ,Tereza Henclová ,Jaroslav Golias ,Jared Balolong ,Luke M Tomasovic ,David Funda ,Aaron S Meyer ,Drew M Pardoll ,Joanna Hester ,Fadi Issa ,Christopher A Hunter ,Mark S Anderson ,Jeffrey A Bluestone ,Giorgio Raimondi ,Jamie B Spangler

Dampened Inflammatory Signalling and Myeloid-Derived Suppressor-Like Cell Accumulation Reduces Circulating Monocytic HLA-DR Density and May Associate With Malignancy Risk in Long-Term Renal Transplant Recipients

炎症信号减弱和髓系抑制样细胞积聚会降低循环单核细胞 HLA-DR 密度,并可能与长期肾移植接受者的恶性肿瘤风险相关

Matthew J Bottomley, Paul N Harden, Kathryn J Wood, Joanna Hester, Fadi Issa

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

缺氧诱导因子调节仓鼠 COVID-19 模型中的传染性 SARS-CoV-2、上皮损伤和呼吸道症状

Peter A C Wing, Maria Prange-Barczynska, Amy Cross, Stefania Crotta, Claudia Orbegozo Rubio, Xiaotong Cheng, James M Harris, Xiaodong Zhuang, Rachel L Johnson, Kathryn A Ryan, Yper Hall, Miles W Carroll, Fadi Issa, Peter Balfe, Andreas Wack, Tammie Bishop, Francisco J Salguero, Jane A McKeating