日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential

磷酸二酯酶抑制剂作为骨骼疾病的新兴疗法:机制和再利用潜力的全面综述

Ursachi, Vlad-Constantin; Horak, Jan; Fafilek, Bohumil

Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors

内质网应激通过改变跨膜受体的加工过程来破坏信号传导。

Bosakova, Michaela; Abraham, Sara P; Wachtell, Davis; Zieba, Jennifer T; Kot, Alexander; Nita, Alexandru; Czyrek, Aleksandra Anna; Koudelka, Adolf; Ursachi, Vlad-Constantin; Feketova, Zuzana; Rico-Llanos, Gustavo; Svozilova, Katerina; Kocerova, Petra; Fafilek, Bohumil; Gregor, Tomas; Kotaskova, Jana; Duran, Ivan; Vanhara, Petr; Doubek, Michael; Mayer, Jiri; Soucek, Karel; Krakow, Deborah; Krejci, Pavel

Increased thermal stability of FGF10 leads to ectopic signaling during development.

FGF10 热稳定性增加导致发育过程中异位信号传导

Czyrek Aleksandra A, Baran Karolina, Hruba Eva, Horackova Aneta, Bosakova Veronika, Chudzian Julia, Fafilek Bohumil, Laskova Veronika, Stepankova Veronika, Bednar David, Karl Kelly, Kasparek Petr, Bosakova Michaela, Killinger Michal, Szotkowska Tereza, Prochazka Jan, Zieba Jennifer T, Rico-Llanos Gustavo, Fric Jan, Hadzic Stefan, Loku Edma, Wujak Magdalena, Svozilova Katerina, Stroblova Michaela, Sedlacek Radislav, Hristova Kalina, Krakow Deborah, Kubovciak Jan, Delattre Mathys, Bartoszewski Rafal, Buchtova Marcela, Krowarsch Daniel, Chaloupkova Radka, Zakrzewska Malgorzata, Krejci Pavel

Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer

DNA适体对成纤维细胞生长因子受体1信号传导的特异性抑制

Zlinska, Vladimira; Feketova, Zuzana; Czyrek, Aleksandra; Chudzian, Julia; Zivkovic, Martina Lenarcic; Ursachi, Vlad-Constantin; Dudeja, Pooja; Fafilek, Bohumil; Rynes, Jan; Rico-Llanos, Gustavo; Koudelka, Adolf; Roy, Tanaya; Biadun, Martyna; Raskova, Vendula; Svozilova, Katerina; Stroblova, Michaela; Krzyscik, Mateusz; Hristova, Kalina; Krowarsch, Daniel; Foldynova-Trantirkova, Silvie; Zakrzewska, Malgorzata; Trantirek, Lukas; Krejci, Pavel

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

肌醇磷酸酶SHIP2通过募集Src激酶,使FGF受体下游的ERK持续激活。

Fafilek, Bohumil; Balek, Lukas; Bosakova, Michaela Kunova; Varecha, Miroslav; Nita, Alexandru; Gregor, Tomas; Gudernova, Iva; Krenova, Jitka; Ghosh, Somadri; Piskacek, Martin; Jonatova, Lucie; Cernohorsky, Nicole H; Zieba, Jennifer T; Kostas, Michal; Haugsten, Ellen Margrethe; Wesche, Jørgen; Erneux, Christophe; Trantirek, Lukas; Krakow, Deborah; Krejci, Pavel

HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies

HIC1通过将TCF-4和β-catenin募集到核体来减弱Wnt信号通路。

Valenta, Tomas; Lukas, Jan; Doubravska, Lenka; Fafilek, Bohumil; Korinek, Vladimir