日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing

Fancl突变小鼠揭示了单泛素化在范可尼贫血症中的核心作用,并为治疗性基因编辑提供了一种模型。

Liu, Lu; Glaser, Astrid; Isiaku, Abdulsalam I; Fairfax, Kirsten; Casolari, Debora A; Ristovski, Angelina; Murphy, Vincent; van Twest, Sylvie; Henrikus, Sarah S; Heraud-Farlow, Jacki; Granger, Elissah; Novakovic, Stevan; Monks O'Byrne, Sophie F; Tsui, Vanessa; Conyers, Rachel; Gonda, Thomas J; Crismani, Wayne; D'Andrea, Richard J; Heierhorst, Jörg; Deans, Andrew J

CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade

CMV血清状态与抗PD-1检查点阻断治疗后生存率提高和毒性发生延迟相关。

Gusztav Milotay #,Martin Little # ,Robert A Watson # ,Dylan Muldoon,Sophie MacKay,Ayako Kurioka,Orion Tong,Chelsea A Taylor,Isar Nassiri,Louisa M Webb,Oluwafemi Akin-Adigun,Julia Bremke,Weiyu Ye,Bo Sun,Piyush Kumar Sharma,Ros Cooper,Sara Danielli,Flavia Matos Santo,Alba Verge de Los Aires,Guangyi Niu,Lea Cohen,Esther Ng,James J Gilchrist,Amanda Y Chong,Alex Mentzer,Victoria Woodcock,Nicholas Coupe,Miranda J Payne,Michael Youdell,Mark R Middleton ,Paul Klenerman,Benjamin P Fairfax

CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade

CMV血清状态与抗PD-1检查点阻断治疗后生存率提高和毒性发生延迟相关。

Gusztav Milotay # ,Martin Little # ,Robert A Watson # ,Dylan Muldoon ,Sophie MacKay ,Ayako Kurioka ,Orion Tong ,Chelsea A Taylor ,Isar Nassiri ,Louisa M Webb ,Oluwafemi Akin-Adigun ,Julia Bremke ,Weiyu Ye ,Bo Sun ,Piyush Kumar Sharma ,Ros Cooper ,Sara Danielli ,Flavia Matos Santo ,Alba Verge de Los Aires ,Guangyi Niu ,Lea Cohen ,Esther Ng ,James J Gilchrist ,Amanda Y Chong ,Alex Mentzer ,Victoria Woodcock ,Nicholas Coupe ,Miranda J Payne ,Michael Youdell ,Mark R Middleton ,Paul Klenerman ,Benjamin P Fairfax

Genetic determinants of monocyte splicing are enriched for disease susceptibility loci

单核细胞剪接的遗传决定因素富集于疾病易感位点

Nassiri, Isar; Gilchrist, James J; Tong, Orion; Lau, Evelyn; Danielli, Sara; Mossawi, Hussein Al; Neville, Matthew J; Knight, Julian C; Fairfax, Benjamin P

Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms

胰腺导管腺癌 (PDAC) 中不同的免疫细胞浸润模式表现出不同的免疫细胞选择和免疫抑制机制。

Shivan Sivakumar # ,Ashwin Jainarayanan # ,Edward Arbe-Barnes # ,Piyush Kumar Sharma # ,Maire Ni Leathlobhair # ,Sakina Amin # ,David J Reiss # ,Lara Heij ,Samarth Hegde ,Assaf Magen ,Felicia Tucci ,Bo Sun ,Shihong Wu ,Nithishwer Mouroug Anand ,Hubert Slawinski ,Santiago Revale ,Isar Nassiri ,Jonathon Webber ,Gerard D Hoeltzel ,Adam E Frampton ,Georg Wiltberger ,Ulf Neumann ,Philip Charlton ,Laura Spiers ,Tim Elliott ,Maria Wang ,Suzana Couto ,Thomas Lila ,Pallavur V Sivakumar ,Alexander V Ratushny ,Mark R Middleton ,Dimitra Peppa ,Benjamin Fairfax ,Miriam Merad ,Michael L Dustin ,Enas Abu-Shah ,Rachael Bashford-Rogers

Identification of conserved immune-related adverse event risk factors and clinical outcomes in a pan-immunotherapy data mart

在泛免疫疗法数据集市中识别保守的免疫相关不良事件风险因素和临床结果

Lamparter, David F; Schmid, Virginia C; Mohindra, Rajat; Karanikas, Vaios; Kam-Thong, Tony; Scepanovic, Petar; Duchateau-Nguyen, Guillemette; Roller, Andreas; Heinzmann, Dominik; Adams, Cameron; Mycroft, Sarah L; Fairfax, Benjamin P; Staedler, Nicolas

Hidden Heterogeneity: How the White Racial Category Masks Interethnic Health Inequality

隐藏的异质性:白人种族类别如何掩盖种族间健康不平等

Read, Jen'nan G; Fairfax, Fatima G

UDP-glucose regulates dendritic cell mitochondrial respiration via a nitric oxide-dependent mechanism

UDP-葡萄糖通过一氧化氮依赖性机制调节树突状细胞线粒体呼吸作用。

Bay Vagher ,Soyeon K Gullickson ,Julia P Snyder ,Tyler Hogan ,Roxana Del Rio-Guerra ,Keke C Fairfax ,Eyal Amiel

Schistosoma mansoni antigen induced innate immune memory features mitochondrial biogenesis and can be inhibited by ovarian produced hormones.

曼氏血吸虫抗原诱导的先天免疫记忆具有线粒体生物合成的特征,可被卵巢产生的激素抑制

Oviedo Juan Marcos, Cortes-Selva Diana, Marchetti Marco, Gordon Lauren, Gibbs Lisa, Maschek J Alan, Cox James, Frietze Seth, Amiel Eyal, Fairfax Keke C

Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy

ARF6介导的肿瘤内在内膜转运形成免疫抑制性微环境,从而驱动黑色素瘤的发生和对免疫检查点阻断疗法的反应。

Yinshen Wee # ,Junhua Wang # ,Emily C Wilson ,Coulson P Rich ,Aaron Rogers ,Zongzhong Tong ,Evelyn DeGroot ,Y N Vashisht Gopal ,Michael A Davies ,H Atakan Ekiz ,Joshua K H Tay ,Chris Stubben ,Kenneth M Boucher ,Juan M Oviedo ,Keke C Fairfax ,Matthew A Williams ,Sheri L Holmen ,Roger K Wolff ,Allie H Grossmann