日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities

脂肪酸硫酯酶A与129个片段结合的晶体结构提供了多种开发机会

Kot, Ekaterina; Ferla, Matteo Paolo; Hollinshead, Patricia Helen; Tomlinson, Charles William Ernest; Fearon, Daren; Aschenbrenner, Jasmin Cara; Koekemoer, Lizbé; Winokan, Max; Fairhead, Michael; Ni, Xiaomin; Chalk, Rod; England, Katherine Sara; Varga, Laura Ortega; Montgomery, Mark Greer; Mulholland, Nicholas Phillip; von Delft, Frank

Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors

结合晶体学片段筛选和深度突变扫描,可以发现寨卡病毒NS2B-NS3蛋白酶抑制剂。

Ni, Xiaomin; Richardson, R Blake; Godoy, Andre Schutzer; Ferla, Matteo P; Kikawa, Caroline; Scheen, Jenke; Hannon, William W; Capkin, Eda; Lahav, Noa; Balcomb, Blake H; Marples, Peter G; Fairhead, Michael; Wang, SiYi; Williams, Eleanor P; Tomlinson, Charles W E; Aschenbrenner, Jasmin C; Lithgo, Ryan M; Winokan, Max; Giroud, Charline; Dolci, Isabela; Fernandes, Rafaela Sachetto; Oliva, Glaucius; Chandran, Anu V; Xavier, Mary-Ann; Walsh, Martin A; Thompson, Warren; Bloom, Jesse D; Kenton, Nathaniel T; Lee, Alpha A; von Delft, Annette; Barr, Haim; Kirkegaard, Karla; Koekemoer, Lizbé; Fearon, Daren; Evans, Matthew J; von Delft, Frank

Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts

胶体提供了一种通过可转移的纳米抗体突变来提高晶体可靠性和多样性的途径,这些突变引入了组成性的紧密接触。

Ye, Mingda; Makola, Mpho; Richards, Mark W; Newman, Joseph A; Fairhead, Michael; Burgess, Selena G; Wu, Zhihuang; Maclean, Elizabeth; Wright, Nathan D; Koekemoer, Lizbé; Thompson, Andrew; Bezerra, Gustavo Arruda; Yi, Gangshun; Li, Huanyu; Rangel, Victor L; Mamalis, Dimitrios; Aitkenhead, Hazel; Davis, Benjamin G; Gilbert, Robert J C; Duerr, Katharina L; Bayliss, Richard; Gileadi, Opher; von Delft, Frank

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

寨卡病毒NS3解旋酶的高通量晶体学片段筛选

Godoy, Andre Schutzer; Giroud, Charline; Mesquita, Nathalya C M R; Noske, Gabriela Dias; Gawriljuk, Victor Oliveira; Lithgo, Ryan M; Balcomb, Blake H; Aschenbrenner, Jasmin Cara; Tomlinson, Charles W E; Winokan, Max; Scheen, Jenke; MacDermott-Opeskin, Hugo; Marples, Peter George; Chandran, Anu V; Ni, Xiaomin; Thompson, Warren; Fairhead, Michael; Fearon, Daren; Koekemoer, Lizbé; Xavier, Mary-Ann Elvina; Walsh, Martin; Oliva, Glaucius; von Delft, Frank

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

柯萨奇病毒A16 2A蛋白酶的晶体学片段筛选为开发广谱抗肠道病毒药物提供了新的契机

Lithgo, Ryan M; Tomlinson, Charles W E; Fairhead, Michael; Winokan, Max; Thompson, Warren; Wild, Conor; Aschenbrenner, Jasmin Cara; Balcomb, Blake H; Marples, Peter G; Chandran, Anu V; Golding, Mathew; Koekemoer, Lizbe; Williams, Eleanor P; Wang, SiYl; Ni, Xiaomin; MacLean, Elizabeth; Giroud, Charline; Godoy, Andre Schutzer; Xavier, Mary-Ann; Walsh, Martin; Fearon, Daren; von Delft, Frank

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening

通过晶体学片段筛选鉴定针对基孔肯雅病毒nsP3宏结构域的新型化学物质

Aschenbrenner, Jasmin C; de Godoy, Andre Schutzer; Fairhead, Michael; Tomlinson, Charles W E; Winokan, Max; Balcomb, Blake H; Capkin, Eda; Chandran, Anu V; Golding, Mathew; Koekemoer, Lizbe; Lithgo, Ryan M; Marples, Peter G; Ni, Xiaomin; Thompson, Warren; Wild, Conor; Xavier, Mary-Ann E; Fearon, Daren; von Delft, Frank

Simultaneous identification of viruses and viral variants with programmable DNA nanobait

利用可编程DNA纳米诱饵同时鉴定病毒及其变种

Bošković, Filip; Zhu, Jinbo; Tivony, Ran; Ohmann, Alexander; Chen, Kaikai; Alawami, Mohammed F; Đorđević, Milan; Ermann, Niklas; Pereira-Dias, Joana; Fairhead, Michael; Howarth, Mark; Baker, Stephen; Keyser, Ulrich F

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease

SARS-CoV-2 NSP15 核糖核酸内切酶的变构调节和晶体学片段筛选

Godoy, Andre Schutzer; Nakamura, Aline Minalli; Douangamath, Alice; Song, Yun; Noske, Gabriela Dias; Gawriljuk, Victor Oliveira; Fernandes, Rafaela Sachetto; Pereira, Humberto D Muniz; Oliveira, Ketllyn Irene Zagato; Fearon, Daren; Dias, Alexandre; Krojer, Tobias; Fairhead, Michael; Powell, Alisa; Dunnet, Louise; Brandao-Neto, Jose; Skyner, Rachael; Chalk, Rod; Bajusz, Dávid; Bege, Miklós; Borbás, Anikó; Keserű, György Miklós; von Delft, Frank; Oliva, Glaucius

Controlling Multivalent Binding through Surface Chemistry: Model Study on Streptavidin

通过表面化学控制多价结合:链霉亲和素的模型研究

Dubacheva, Galina V; Araya-Callis, Carolina; Geert Volbeda, Anne; Fairhead, Michael; Codée, Jeroen; Howarth, Mark; Richter, Ralf P

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

超越结构基因组学的SGC:通过将基因组分层与基于片段的发现相结合,重新定义3D结构的作用

Bradley, Anthony R; Echalier, Aude; Fairhead, Michael; Strain-Damerell, Claire; Brennan, Paul; Bullock, Alex N; Burgess-Brown, Nicola A; Carpenter, Elisabeth P; Gileadi, Opher; Marsden, Brian D; Lee, Wen Hwa; Yue, Wyatt; Bountra, Chas; von Delft, Frank