日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model.

在猪模型中，皮内注射亲脂性siRNA可实现皮肤长期滞留和持续基因沉默。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-68993-1
Fakih Hassan H, Zain Ui Abideen Mohammad, Rachid Mohamad Omar, Gross Katherine Y, Ormsby Thomas J R, Ross Vella M, Gagnon Rosemary, Dahlke Christopher, Furgal Raymond C, Lochmann Clemens, Summers Ashley, Sleiman Hanadi F, Fürst Sylvia M, Jackson Shanté N, Gordilho Juliana O, Bouix-Peter Claire, Portal Thibaud, Tang Qi, Harris John E, Khvorova Anastasia, Blanchard Carine, Alterman Julia F
表观遗传
发表日期：2026
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Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo

引导RNA 3'末端区域中磷酸二酯骨架的存在（而非核碱基的存在）是RISC在体外和体内装载和靶标切割所必需的。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf1438
O'Reilly, Daniel; Furgal, Raymond C; Ross, Vella M; Luu, Eric; Gross, Katherine Y; Hariharan, Vignesh; Summers, Ashley; Cooper, David; Allen, Sarah; Dahlke, Christopher; Rachid, Mohamad Omar; Chan, Io Long; Fakih, Hassan H; Alterman, Julia F; Echeverria, Dimas; Watts, Jonathan K; Khvorova, Anastasia
发表日期：2026
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Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth.

将靶向 IRS2 的白蛋白结合 siRNA 治疗性递送至多种细胞类型可减少乳腺肿瘤的生长。

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2026.01.033
Tocheny Claire E, Buchwald Julianna E, Dahlke Christopher D, Fakih Hassan H, Morgan Jennifer S, Summers Ashley, Silva Christi A, Jackson Samuel O, Lee Ji-Sun, Card Michael-Anthony, Echeverria Dimas, Peterson Cornelia, Mercurio Arthur M, Khvorova Anastasia, Shaw Leslie M
细胞生物学
肿瘤
RS2
肿瘤免疫
发表日期：2026
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Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs

利用化学成分明确的亲脂性siRNA在心脏和肌肉中实现高效持久的基因调控

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf1374
Fakih, Hassan H; Lochmann, Clemens; Gagnon, Rosemary; Summers, Ashley; Caiazzi, Jillian; Buchwald, Julianna E; Tang, Qi; Maru, Bruktawit; Hildebrand, Samuel R; Abideen, Mohammad Zain U I; Furgal, Raymond C; Gross, Katherine Y; Yang, Yeon-Suk; Cooper, David; Monopoli, Kathryn R; Echeverria, Dimas; Shim, Jae-Hyuck; Yamada, Ken; Alterman, Julia F; Khvorova, Anastasia
信号转导
发表日期：2025
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A Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases.

治疗性小干扰RNA增强Janus激酶1调节作用，用于治疗犬类炎症性疾病

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.4c00594
Tang Qi, Fakih Hassan H, Gross Katherine Y, Winter Sarah J, Bramato Brianna M, Yıldız-Altay Ümmügülsüm, Chang Benjamin K, Echeverria Dimas, Jackson Samuel O, McHugh Nicholas, Srnka Alyxandr, Alterman Julia F, Almela Ramón M, Kudej Raymond K, London Cheryl A, Richmond Jillian M, Harris John E, Khvorova Anastasia
免疫/内分泌
炎症
发表日期：2025
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Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system

白蛋白结合树状聚合物偶联的siRNA能够安全有效地在整个中枢神经系统中进行基因沉默。

期刊:
影响因子:
doi:10.64898/2025.12.16.694641
Fakih, Hassan H; Ohara, Masahiro; Summers, Ashley; Sarli, Samantha L; Kelly, Karen; Gagnon, Rosemary; Maru, Bruktawit; Bramato, Brianna; Khvorova, Anastasia; Watts, Jonathan K
表观遗传
神经科学
发表日期：2025
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Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth

将靶向IRS2的白蛋白结合siRNA治疗性递送至多种细胞类型可减少乳腺肿瘤的生长

期刊:
影响因子:
doi:10.1101/2025.07.29.667434
Tocheny, Claire E; Buchwald, Julianna E; Dahlke, Christopher D; Fakih, Hassan H; Morgan, Jennifer S; Summers, Ashley; Wisniewski, Christi A; Jackson, Samuel O; Lee, Ji-Sun; Card, Michael-Anthony; Echeverria, Dimas; Peterson, Cornelia; Mercurio, Arthur M; Khvorova, Anastasia; Shaw, Leslie M
RS2
细胞生物学
肿瘤
肿瘤免疫
发表日期：2025
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Editorial: Nucleic Acids Research virtual issue dedicated to nucleic acid therapeutics, 2018-2023

社论：核酸研究虚拟特刊，聚焦核酸疗法，2018-2023

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkad1148
Belgrad, Jillian; Fakih, Hassan H; Johnson, Krystal C; Corey, David R
发表日期：2024
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Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.

量化 ASO 和 siRNA 缀合物在胶质母细胞瘤异种移植瘤体内的活性谱

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkae260
Sarli Samantha L, Fakih Hassan H, Kelly Karen, Devi Gitali, Rembetsy-Brown Julia M, McEachern Holly R, Ferguson Chantal M, Echeverria Dimas, Lee Jonathan, Sousa Jacquelyn, Sleiman Hanadi F, Khvorova Anastasia, Watts Jonathan K
细胞生物学
发表日期：2024
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Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation

核酸疗法：成功案例、里程碑及未来创新

期刊:Nucleic Acid Therapeutics
影响因子:4.7
doi:10.1089/nat.2023.0068
Belgrad, Jillian; Fakih, Hassan H; Khvorova, Anastasia
发表日期：2024
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