日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators

合成氨基糖苷 ELX-02 可诱导 G550X-CFTR 读通,产生超功能蛋白质,而 CFTR 调节剂可进一步增强该蛋白质的功能

Jianguo Chen, Kari Thrasher, Lianwu Fu, Wei Wang, Soheil Aghamohammadzadeh, Hui Wen, Liping Tang, Kim M Keeling, Emily Falk Libby, David M Bedwell, Steven M Rowe

Evaluation of a novel CFTR potentiator in COPD ferrets with acquired CFTR dysfunction

对患有获得性 CFTR 功能障碍的 COPD 雪貂进行新型 CFTR 增效剂的评估

Niroop Kaza, Vivian Y Lin, Denise Stanford, Shah S Hussain, Emily Falk Libby, Harrison Kim, Monica Borgonovi, Katja Conrath, Venkateshwar Mutyam, Stephen A Byzek, Li Ping Tang, John E Trombley, Lawrence Rasmussen, Trenton Schoeb, Hui Min Leung, Guillermo J Tearney, S Vamsee Raju, Steven M Rowe

Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

人类 COPD 的比较转录组学揭示了雪貂中独特表达的失调基因

Shah S Hussain #, Yvonne J K Edwards #, Emily Falk Libby, Denise Stanford, Stephen A Byzek, Don D Sin, Merry-Lynn McDonald, S Vamsee Raju, Steven M Rowe

Preclinical evaluation of the epithelial sodium channel inhibitor AZD5634 and implications on human translation

上皮钠通道抑制剂 AZD5634 的临床前评估及其对人类翻译的影响

Annika Åstrand, Emily Falk Libby, Ren-Jay Shei, Jacelyn E Peabody Lever, Niroop Kaza, Adegboyega Timothy Adewale, Evan Boitet, Lloyd Edwards, Martin Hemmerling, James Root, Botilda Lindberg, Cecilia Wingren, Anna Malmgren, Juan Sabater, Steven M Rowe

Novel Correctors and Potentiators Enhance Translational Readthrough in CFTR Nonsense Mutations

新型校正剂和增强剂可提高CFTR无义突变中的翻译通读

Mutyam, Venkateshwar; Sharma, Jyoti; Li, Yao; Peng, Ning; Chen, Jianguo; Tang, Li Ping; Falk Libby, Emily; Singh, Ashvani K; Conrath, Katja; Rowe, Steven M

Novel Therapy of Bicarbonate, Glutathione, and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport

一种新型的碳酸氢盐、谷胱甘肽和抗坏血酸疗法可改善囊性纤维化粘液转运。

Adewale, Adegboyega Timothy; Falk Libby, Emily; Fu, Lianwu; Lenzie, Andrew; Boitet, Evan R; Birket, Susan E; Petty, Courtney Fernandez; Johns, J Dixon; Mazur, Marina; Tearney, Guillermo J; Copeland, Dan; Durham, Carolyn; Rowe, Steven M

A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus

糖聚合物可改善异常囊性纤维化粘液的血管弹性和粘膜纤毛运输

Courtney M Fernandez-Petty, Gareth W Hughes, Hannah L Bowers, John D Watson, Bradley H Rosen, Stacy M Townsend, Carlo Santos, Caroline E Ridley, Kengyeh K Chu, Susan E. Birket, Yao Li, Hui Min Leung, Marina Mazur, Bryan A Garcia, T Idil Apak Evans, Emily Falk Libby, Heather Hathorne, Justin Hanes, G

Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations

发现经临床批准的促进抑制囊性纤维化跨膜传导调节器无义突变的药物

Venkateshwar Mutyam, Ming Du, Xiaojiao Xue, Kim M Keeling, E Lucile White, J Robert Bostwick, Lynn Rasmussen, Bo Liu, Marina Mazur, Jeong S Hong, Emily Falk Libby, Feng Liang, Haibo Shang, Martin Mense, Mark J Suto, David M Bedwell, Steven M Rowe

Increased autophagic response in a population of metastatic breast cancer cells

转移性乳腺癌细胞群自噬反应增强

Y I Li, Emily Falk Libby, Monica J Lewis, Jianzhong Liu, John J Shacka, Douglas R Hurst

Globular adiponectin enhances invasion in human breast cancer cells

球状脂联素增强人类乳腺癌细胞的侵袭

Emily Falk Libby, Jianzhong Liu, Y I Li, Monica J Lewis, Wendy Demark-Wahnefried, Douglas R Hurst