ELK1 inhibition alleviates amyloid pathology and memory decline by promoting the SYVN1-mediated ubiquitination and degradation of PS1 in Alzheimer's disease.
ELK1 抑制通过促进 SYVN1 介导的 PS1 泛素化和降解来减轻阿尔茨海默病中的淀粉样蛋白病理和记忆力衰退
期刊:Experimental and Molecular Medicine
影响因子:12.9
doi:10.1038/s12276-025-01455-8
Yi Lilin, Li Junjie, He Yan, Wang Jiaojiao, Wang Maoju, Guo Song, Luo Man, Wu Bin, Xu Mingliang, Tian Qiuyun, Fan Yepeng, Chen Mulan, Xu Boqing, Xia Lei, Song Weihong, He Guiqiong, Du Yehong, Dong Zhifang
