日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib.

CHK1抑制剂在小细胞肺癌中对生物标志物定义的疾病亚群具有单药活性,并与顺铂或奥拉帕尼联合使用具有联合活性

Sen Triparna, Tong Pan, Stewart C Allison, Cristea Sandra, Valliani Aly, Shames David S, Redwood Abena B, Fan You Hong, Li Lerong, Glisson Bonnie S, Minna John D, Sage Julien, Gibbons Don L, Piwnica-Worms Helen, Heymach John V, Wang Jing, Byers Lauren Averett

Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies

TTF1 和 cMYC 蛋白的表达定义了小细胞肺癌的不同分子亚群,这些亚群对 Aurora 激酶抑制剂、DLL3 靶向治疗和其他靶向疗法具有独特的敏感性。

Cardnell, Robert J; Li, Lerong; Sen, Triparna; Bara, Rasha; Tong, Pan; Fujimoto, Junya; Ireland, Abbie S; Guthrie, Matthew R; Bheddah, Sheila; Banerjee, Upasana; Kalu, Nene N; Fan, You-Hong; Dylla, Scott J; Johnson, Faye M; Wistuba, Ignacio I; Oliver, Trudy G; Heymach, John V; Glisson, Bonnie S; Wang, Jing; Byers, Lauren A

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

上皮-间质转化与肺腺癌中独特的肿瘤微环境相关,包括炎症信号的升高和多个免疫检查点的激活。

Lou, Yanyan; Diao, Lixia; Cuentas, Edwin Roger Parra; Denning, Warren L; Chen, Limo; Fan, You Hong; Byers, Lauren A; Wang, Jing; Papadimitrakopoulou, Vassiliki A; Behrens, Carmen; Rodriguez, Jaime Canales; Hwu, Patrick; Wistuba, Ignacio I; Heymach, John V; Gibbons, Don L

Characterizing the molecular spatial and temporal field of injury in early-stage smoker non-small cell lung cancer patients after definitive surgery by expression profiling

通过表达谱分析表征早期吸烟非小细胞肺癌患者根治性手术后分子损伤的空间和时间场

Kadara, Humam; Shen, Li; Fujimoto, Junya; Saintigny, Pierre; Chow, Chi-Wan; Lang, Wenhua; Chu, Zuoming; Garcia, Melinda; Kabbout, Mohamed; Fan, You-Hong; Behrens, Carmen; Liu, Diane A; Mao, Li; Lee, J Jack; Gold, Kathryn A; Wang, Jing; Coombes, Kevin R; Kim, Edward S; Hong, Waun Ki; Wistuba, Ignacio I

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1

蛋白质组学分析揭示了小细胞肺癌中失调的通路以及包括PARP1在内的新型治疗靶点。

Byers, Lauren Averett; Wang, Jing; Nilsson, Monique B; Fujimoto, Junya; Saintigny, Pierre; Yordy, John; Giri, Uma; Peyton, Michael; Fan, You Hong; Diao, Lixia; Masrorpour, Fatemeh; Shen, Li; Liu, Wenbin; Duchemann, Boris; Tumula, Praveen; Bhardwaj, Vikas; Welsh, James; Weber, Stephanie; Glisson, Bonnie S; Kalhor, Neda; Wistuba, Ignacio I; Girard, Luc; Lippman, Scott M; Mills, Gordon B; Coombes, Kevin R; Weinstein, John N; Minna, John D; Heymach, John V

Gene expression profiling predicts the development of oral cancer

基因表达谱分析可预测口腔癌的发生发展

Saintigny, Pierre; Zhang, Li; Fan, You-Hong; El-Naggar, Adel K; Papadimitrakopoulou, Vassiliki A; Feng, Lei; Lee, J Jack; Kim, Edward S; Ki Hong, Waun; Mao, Li

Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer

表皮生长因子受体表达和基因拷贝数与口腔癌风险的关系

Taoudi Benchekroun, Mohammed; Saintigny, Pierre; Thomas, Sufi M; El-Naggar, Adel K; Papadimitrakopoulou, Vassiliki; Ren, Hening; Lang, Wenhua; Fan, You-Hong; Huang, Jianhua; Feng, Lei; Lee, J Jack; Kim, Edward S; Hong, Waun Ki; Johnson, Faye M; Grandis, Jennifer R; Mao, Li

DeltaNp63 overexpression, alone and in combination with other biomarkers, predicts the development of oral cancer in patients with leukoplakia

DeltaNp63 过表达,单独或与其他生物标志物联合,可预测白斑患者发生口腔癌的风险。

Saintigny, Pierre; El-Naggar, Adel K; Papadimitrakopoulou, Vali; Ren, Hening; Fan, You-Hong; Feng, Lei; Lee, J Jack; Kim, Edward S; Hong, Waun Ki; Lippman, Scott M; Mao, Li

Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs

口腔上皮作为替代组织用于评估吸烟引起的肺部分子改变

Bhutani, Manisha; Pathak, Ashutosh Kumar; Fan, You-Hong; Liu, Diane D; Lee, J Jack; Tang, Hongli; Kurie, Jonathan M; Morice, Rodolfo C; Kim, Edward S; Hong, Waun Ki; Mao, Li

Impact of smoking cessation on global gene expression in the bronchial epithelium of chronic smokers

戒烟对慢性吸烟者支气管上皮细胞整体基因表达的影响

Zhang, Li; Lee, J Jack; Tang, Hongli; Fan, You-Hong; Xiao, Lianchun; Ren, Hening; Kurie, Jonathan; Morice, Rodolfo C; Hong, Waun Ki; Mao, Li