文献库，生知库 | 链接生命科学的每一步

Georgescauld, Florian; Okekenwa, Sonia; Boyd, Tanner; Donahue, Cameron; Quittot, Noe; Dickson, John R; Fan, Zhanyun; Brady, Scott; Blackstone, Craig; Hyman, Bradley; Song, Yuyu

毒理研究

神经科学

发表日期：2026

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Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons.

阿尔茨海默病患者体内产生的高分子量 tau 蛋白会损害海马神经元的爆发性放电

期刊:Cell

影响因子:42.5

doi:10.1016/j.cell.2025.04.006

Harris Samuel S, Ellingford Robert, Hartmann Jana, Dasgupta Debanjan, Kehring Marten, Rajani Rikesh M, Graykowski David, Quittot NoÃ©, Sivasankaran Dhanush, Commins Caitlin, Fan Zhanyun, Bond Suraya A, Wolf Fred, Dupret David, Dolan Raymond J, Konnerth Arthur, Neef Andreas, Hyman Bradley T, Busche Marc Aurel

Alzheimer disease-associated tau post-translational modification mimics impact tau propagation and uptake.

阿尔茨海默病相关的 tau 蛋白翻译后修饰模拟物会影响 tau 蛋白的传播和吸收

期刊:Journal of Neuropathology and Experimental Neurology

影响因子:3

doi:10.1093/jnen/nlaf007

Dickson John R, Sobolewski Robert G R, Fernandes Analiese R, Cooper Joanna M, Fan Zhanyun, Chung Mirra, Donahue Cameron, Oakley Derek H, Strickland Dudley K, Hyman Bradley T

其它

发表日期：2025

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Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau(297-391) Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM

利用重组Tau(297-391)重建阿尔茨海默病Tau蛋白核心结构，通过负染和冷冻电镜观察，可获得不同的四级结构。

期刊:Biochemistry

影响因子:3

doi:10.1021/acs.biochem.3c00425

Glynn, Calina; Chun, Joshua E; Donahue, Cameron C; Nadler, Monica J S; Fan, Zhanyun; Hyman, Bradley T

阿尔茨海默症

发表日期：2024

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Conformational fingerprinting of tau variants and strains by Raman spectroscopy.

利用拉曼光谱对 tau 变体和菌株进行构象指纹图谱分析

期刊:RSC Advances

影响因子:4.6

doi:10.1039/d1ra00870f

Devitt George, Crisford Anna, Rice William, Weismiller Hilary A, Fan Zhanyun, Commins Caitlin, Hyman Bradley T, Margittai Martin, Mahajan Sumeet, Mudher Amrit

微生物学

发表日期：2021

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Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

糖原合成酶激酶-3β (GSK-3β) 的亚型选择性降低可减少突触 tau 蛋白的磷酸化、跨细胞扩散和聚集。

期刊:iScience

影响因子:4.1

doi:10.1016/j.isci.2021.102058

Amaral, Ana Claudia; Perez-Nievas, Beatriz G; Siao Tick Chong, Michael; Gonzalez-Martinez, Alicia; Argente-Escrig, Herminia; Rubio-Guerra, Sara; Commins, Caitlin; Muftu, Serra; Eftekharzadeh, Bahareh; Hudry, Eloise; Fan, Zhanyun; Ramanan, Prianca; Takeda, Shuko; Frosch, Matthew P; Wegmann, Susanne; Gomez-Isla, Teresa

Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9

外周注射AAV9后，在中枢神经系统特定细胞类型中实现定制化的转基因表达

期刊:Molecular Therapy-Methods & Clinical Development

影响因子:4.7

doi:10.1038/mtm.2016.81

Dashkoff, Jonathan; Lerner, Eli P; Truong, Nhi; Klickstein, Jacob A; Fan, Zhanyun; Mu, Dakai; Maguire, Casey A; Hyman, Bradley T; Hudry, Eloise

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

去除内源性tau蛋白并不能阻止tau蛋白的增殖，但可以降低其神经毒性。

期刊:EMBO Journal

影响因子:8.3

doi:10.15252/embj.201592748

Wegmann, Susanne; Maury, Eduardo A; Kirk, Molly J; Saqran, Lubna; Roe, Allyson; DeVos, Sarah L; Nicholls, Samantha; Fan, Zhanyun; Takeda, Shuko; Cagsal-Getkin, Ozge; William, Christopher M; Spires-Jones, Tara L; Pitstick, Rose; Carlson, George A; Pooler, Amy M; Hyman, Bradley T

毒理研究

发表日期：2015

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Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss

长期使用新型小分子Hsp90抑制剂可恢复纹状体多巴胺水平，但不能挽救α-突触核蛋白诱导的神经元细胞丢失。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0086048

McFarland, Nikolaus R; Dimant, Hemi; Kibuuka, Laura; Ebrahimi-Fakhari, Darius; Desjardins, Cody A; Danzer, Karin M; Danzer, Michael; Fan, Zhanyun; Schwarzschild, Michael A; Hirst, Warren; McLean, Pamela J

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics

直接可视化体内CHIP介导的α-突触核蛋白降解：对帕金森病治疗的启示

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0092098

Dimant, Hemi; Zhu, Liya; Kibuuka, Laura N; Fan, Zhanyun; Hyman, Bradley T; McLean, Pamela J

Dynamic conformational ensembles of soluble Tau encode neuronal toxicity prior to aggregation

可溶性Tau蛋白的动态构象集合在聚集之前就编码了神经元毒性。

Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons.

阿尔茨海默病患者体内产生的高分子量 tau 蛋白会损害海马神经元的爆发性放电

Alzheimer disease-associated tau post-translational modification mimics impact tau propagation and uptake.

阿尔茨海默病相关的 tau 蛋白翻译后修饰模拟物会影响 tau 蛋白的传播和吸收

Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau(297-391) Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM

利用重组Tau(297-391)重建阿尔茨海默病Tau蛋白核心结构，通过负染和冷冻电镜观察，可获得不同的四级结构。

Conformational fingerprinting of tau variants and strains by Raman spectroscopy.

利用拉曼光谱对 tau 变体和菌株进行构象指纹图谱分析

Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

糖原合成酶激酶-3β (GSK-3β) 的亚型选择性降低可减少突触 tau 蛋白的磷酸化、跨细胞扩散和聚集。

Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9

外周注射AAV9后，在中枢神经系统特定细胞类型中实现定制化的转基因表达

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

去除内源性tau蛋白并不能阻止tau蛋白的增殖，但可以降低其神经毒性。

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss

长期使用新型小分子Hsp90抑制剂可恢复纹状体多巴胺水平，但不能挽救α-突触核蛋白诱导的神经元细胞丢失。

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics

直接可视化体内CHIP介导的α-突触核蛋白降解：对帕金森病治疗的启示