日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Allosteric Induction of Estrogen Receptor Ligand Binding Domain Tetramerization by a Distinct Complete Estrogen Receptor Antagonist

一种独特的完全雌激素受体拮抗剂对雌激素受体配体结合域四聚化的变构诱导作用

Fink, Emma C; Chawla, Reena; Hancock, Govinda R; Wells, Kylie S; Barratt, Susanna; Myles, David C; Peña, Guadalupe; Robello, Brandon W; Hearn, Brian R; Fanning, Sean W

Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers

抑制NR2F2可恢复内分泌难治性乳腺癌的激素治疗反应

Cai, Yanyan; Zhao, Peihua; Wu, Fan; Zhao, Huiyong; Shao, Hong; Marra, Antonio; Patel, Payal; O'Connell, Elizabeth; Fink, Emma; Miele, Matthew M; Li, Zhuoning; De Stanchina, Elisa; Cocco, Emiliano; Razavi, Pedram; Toska, Eneda; Fanning, Sean W; Xu, Guotai; Sablina, Anna A; Scaltriti, Maurizio; Chandarlapaty, Sarat

Imlunestrant a next-generation oral SERD overcomes ESR1 mutant resistance in estrogen receptor-positive breast cancer.

新一代口服SERD药物Imlunestrant可克服雌激素受体阳性乳腺癌中的ESR1突变耐药性

Sherman Shira, Sandusky Zachary M, Russo Douglas, Zak David, Nardone Agostina, Friel Delia, Hermida-Prado Francisco, Heraud Capucine, Kuziel Genevra, Verma Ana, Gaglia Giorgio, Kabraji Sheheryar, Nguyen Quang-De, Santagata Sandro, Fanning Sean W, Jeselsohn Rinath

OR04-08 Ligand Class Analysis Enables Predictive Models for Effective Antagonism of Endocrine Resistant Breast Cancer

OR04-08 配体类别分析可构建预测模型,有效拮抗内分泌耐药性乳腺癌

Ravani, Victoria Lis; Bagheri, Zahra; Brufsky, Adam M; Michelon, Isabella; O'Regan, Ruth; Lustberg, Maryam; Han, Hyo; Wang, Ming; Wander, Seth A; Nwachukwu, Jerome C; Min, Charles K; Kobylski, Robin R; Kim, Tahchur J; Hou, Yingwei; Kim, Sung Hoon; Hancock, Govinda R; Izard, Tina; Fanning, Sean W; Katzenellenbogen, Benita S; Katzenellenbogen, John A; Nettles, Kendall W

Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD).

发现帕拉塞斯特兰(OP-1250),一种强效且口服生物利用度高的完全雌激素受体拮抗剂(CERAN)和选择性雌激素受体降解剂(SERD)

Ng Raymond A, Barratt Susanna, Parisian Alison, Palanisamy Gopinath S, Phukan Samiron, Sun Richard, Robello Brandon, Peña Guadalupe, Sapugay Judevin, Yeghikyan David, Wang Chenbo, Satish Kher Samir, Thangathirupathy Srinivasan, Millikin Robert, Yu Guijun, Watanabe Teruki, Zhou Fei, Rich Brian, Duncan Alexis, Andersen Samuel E, Chawla Reena, Zak David R, Heerding Dirk A, Hearn Brian R, Greene Geoffrey, Harmon Cyrus L, Hodges-Gallagher Leslie, Kushner Peter J, Fanning Sean W, Myles David C

Benzestrol Isomer Stereochemistry Determines the Distinct Estrogenic Activities and Conformations of the Eight Isomers When Bound to Estrogen Receptor α.

苯雌酚异构体的立体化学决定了八种异构体与雌激素受体α结合时不同的雌激素活性和构象

Hou Yingwei, Nwachukwu Jerome C, Carlson Kathryn, Kim Sung Hoon, Angle Samantha, Jacobsen Eric N, Woods Toby, Mateus Sofia L, Fanning Sean W, Ziegler Yvonne, Katzenellenbogen Benita S, Nettles Kendall W, Katzenellenbogen John A

SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancer.

SOX2 利用 FOXA1 作为异源转录伙伴来驱动耐药性前列腺癌的增殖

Phoenix John T, Budreika Audris, Schmeck Devin A, Kostlan Raymond J, Ferrari Marina G, Young Kristen S, Rogers Charles S, Deegan Carleen D, Bienko Marcus W, Bergom Hannah E, Boytim Ella, Brown Ryan M, Walewicz Julia A, Bhagi Shreya K, Ellis Leigh, Antonarakis Emmanuel S, Drake Justin M, Bawa Pushpinder S, Vellky Jordan E, Williams Anthony, Rezine Natalie M, Rennhack Jonathan P, Fanning Sean W, Hwang Justin H, Szmulewitz Russell Z, Vander Griend Donald J, Kregel Steven

Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies

雌激素受体α突变、截断、异二聚体和疗法

Hancock, Govinda R; Gertz, Jason; Jeselsohn, Rinath; Fanning, Sean W

Editorial: Hormone resistance in cancer

社论:癌症中的激素抵抗

Phoenix, John T; Budreika, Audris; Kostlan, Raymond J; Hwang, Justin H; Fanning, Sean W; Kregel, Steven

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells

立体特异性拉索昔芬衍生物揭示了雌激素受体α稳定性与ESR1突变型乳腺癌细胞拮抗活性之间的相互作用

Hosfield, David J; Weber, Sandra; Li, Nan-Sheng; Sauvage, Madline; Joiner, Carstyn F; Hancock, Govinda R; Sullivan, Emily A; Ndukwe, Estelle; Han, Ross; Cush, Sydney; Lainé, Muriel; Mader, Sylvie C; Greene, Geoffrey L; Fanning, Sean W