日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

在随机临床试验中,研究性 eIF2B 激活剂 DNL343 可调节 TDP-43 病理临床前模型和 ALS 患者的整合应激反应。

Brittany N Flores # ,Seungyoon B Yu # ,Isaac V Cohen # ,Melania H Fanok # ,Wei Luan ,Romeo D Maciuca ,Linus D Sun ,Richard M Tsai ,Maurits Vissers ,Lars Smits ,Tommy M Bunte ,Anna Bakardjiev ,Srijana Balasundar ,Meredith E K Calvert ,Marcus Y Chin ,Sarah K Dobbins ,William E Dowdle ,Meng Fang ,Jules A A C Heuberger ,Connie L Ha ,Fen Huang ,Takashi Miyamoto ,Maksim Osipov ,Lidia Madrid San Martin ,Katie Saund ,David Tatarakis ,Anthony Q Vu ,Chenling Xiong ,Gene W Yeo ,Geert Jan Groeneveld ,Leonard H van den Berg ,Shyeilla Dhuria ,Anthony A Estrada ,Danna Jennings ,Thomas Sandmann ,Carole Ho ,Kimberly Scearce-Levie ,Ernie Yulyaningsih ,Adam K Walker ,Gilbert Di Paolo ,Lesley A Kane ,Matthew D Troyer ,Joseph W Lewcock

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

DNL343 是一种在研的中枢神经系统渗透性真核起始因子 2B 激活剂,可预防和逆转由综合应激反应引起的神经退行性的影响

Ernie Yulyaningsih #, Jung H Suh, Melania Fanok #, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick C G Haddick, Kirk R Henne, Martin Larhammar

Stepping in and up to meet community needs: How community-based college access and success programs responded to COVID-19

积极响应社区需求:社区大学入学和成功项目如何应对新冠疫情

Case, Amanda S; Kang, Ellice; Krutsch, Jacqueline; Bhojwani, Jaya; Fanok, Sophie; Contreras, Stephanie

Augmented Th17 Differentiation Leads to Cutaneous and Synovio-Entheseal Inflammation in a Novel Model of Psoriatic Arthritis

在一种新型银屑病关节炎模型中,Th17细胞分化增强导致皮肤和滑膜-肌腱端炎症

Yang, Lu; Fanok, Melania H; Mediero-Munoz, Aranzazu; Fogli, Laura K; Corciulo, Carmen; Abdollahi, Shahla; Cronstein, Bruce N; Scher, Jose U; Koralov, Sergei B

Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma

细胞因子信号传导失调和细菌触发因素在皮肤T细胞淋巴瘤发病机制中的作用

Fanok, Melania H; Sun, Amy; Fogli, Laura K; Narendran, Vijay; Eckstein, Miriam; Kannan, Kasthuri; Dolgalev, Igor; Lazaris, Charalampos; Heguy, Adriana; Laird, Mary E; Sundrud, Mark S; Liu, Cynthia; Kutok, Jeff; Lacruz, Rodrigo S; Latkowski, Jo-Ann; Aifantis, Iannis; Ødum, Niels; Hymes, Kenneth B; Goel, Swati; Koralov, Sergei B

Cryptosporidium Attenuation across the Wastewater Treatment Train: Recycled Water Fit for Purpose

废水处理过程中隐孢子虫的衰减:再生水符合用途

King, Brendon; Fanok, Stella; Phillips, Renae; Lau, Melody; van den Akker, Ben; Monis, Paul

Integrated cryptosporidium assay to determine oocyst density, infectivity, and genotype for risk assessment of source and reuse water

综合隐孢子虫检测以确定卵囊密度、感染性和基因型,以进行水源和回用水的风险评估

Brendon King, Stella Fanok, Renae Phillips, Brooke Swaffer, Paul Monis

Leptin receptor signaling in T cells is required for Th17 differentiation

细胞中的瘦素受体信号传导是 Th17 分化所必需的

Bernardo S Reis, Kihyun Lee, Melania H Fanok, Cristina Mascaraque, Manal Amoury, Lillian B Cohn, Aneta Rogoz, Olof S Dallner, Pedro M Moraes-Vieira, Ana I Domingos, Daniel Mucida

Cell culture-Taqman PCR assay for evaluation of Cryptosporidium parvum disinfection

细胞培养-Taqman PCR检测法用于评估小隐孢子虫的消毒效果

Keegan, Alexandra R; Fanok, Stella; Monis, Paul T; Saint, Christopher P