日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases

可编程mRNA疗法用于控制多种疾病中单基因和多基因表达的表观基因组调控

Charles W O'Donnell # ,Jeremiah D Farelli # ,Houda Belaghzal # ,Justin Chen # ,Lauren Beech ,James Sullivan ,Chevaun Morrison-Smith ,Stephen Siecinski ,Adam Katz ,Samuel Mildrum ,Mayur Gurnani ,Prachi Dhanania ,Caitlyn R Webb ,Giuliana Castello Coatti ,Pranjali Rumale ,Daniel F G Costa ,Marcus I Gibson ,Yaoyu E Wang ,Joseph V Newman ,Thomas G McCauley

Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models

利用表观基因组调控因子靶向下调MYC转录,在肝细胞癌模型中显示出抗肿瘤活性。

William Senapedis ,Kayleigh M Gallagher ,Elmer Figueroa ,Jeremiah D Farelli ,Robert Lyng ,J Graeme Hodgson ,Charles W O'Donnell ,Joseph V Newman ,Madison Pacaro ,Stephen K Siecinski ,Justin Chen ,Thomas G McCauley

Does depth divide? Variable genetic connectivity patterns among shallow and mesophotic Montastraea cavernosa coral populations across the Gulf of Mexico and western Caribbean

深度有区别吗?墨西哥湾和西加勒比海浅水和中光层 Montastraea cavernosa 珊瑚种群间存在不同的遗传连接模式

Alexis B Sturm, Ryan J Eckert, Ashley M Carreiro, Allison M Klein, Michael S Studivan, Danielle Dodge Farelli, Nuno Simões, Patricia González-Díaz, Juliett González Méndez, Joshua D Voss

G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a

G6PC mRNA 疗法可积极调节空腹血糖并减少糖原累积症 1a 小鼠模型中的肝脏异常

Daniel S Roseman, Tayeba Khan, Fabienne Rajas, Lucy S Jun, Kirtika H Asrani, Cleo Isaacs, Jeremiah D Farelli, Romesh R Subramanian

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis

枯草芽孢杆菌两个基因组规模缺失文库的构建与分析

Byoung-Mo Koo, George Kritikos, Jeremiah D Farelli, Horia Todor, Kenneth Tong, Harvey Kimsey, Ilan Wapinski, Marco Galardini, Angelo Cabal, Jason M Peters, Anna-Barbara Hachmann, David Z Rudner, Karen N Allen, Athanasios Typas, Carol A Gross

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer

具有多种抑制和潜在促肿瘤活性的调节性 T 细胞在人类结直肠癌中聚集

Eleonora Timperi, Ilenia Pacella, Valeria Schinzari, Chiara Focaccetti, Luca Sacco, Francesco Farelli, Roberto Caronna, Gabriella Del Bene, Flavia Longo, Antonio Ciardi, Sergio Morelli, Anna Rita Vestri, Piero Chirletti, Vincenzo Barnaba, Silvia Piconese

Panoramic view of a superfamily of phosphatases through substrate profiling

通过底物谱分析对磷酸酶超家族进行全景式观察

Huang, Hua; Pandya, Chetanya; Liu, Chunliang; Al-Obaidi, Nawar F; Wang, Min; Zheng, Li; Toews Keating, Sarah; Aono, Miyuki; Love, James D; Evans, Brandon; Seidel, Ronald D; Hillerich, Brandan S; Garforth, Scott J; Almo, Steven C; Mariano, Patrick S; Dunaway-Mariano, Debra; Allen, Karen N; Farelli, Jeremiah D

Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases

共价对接预测卤代烷酸脱卤酶超家族磷酸酶的底物

Nir London, Jeremiah D Farelli, Shoshana D Brown, Chunliang Liu, Hua Huang, Magdalena Korczynska, Nawar F Al-Obaidi, Patricia C Babbitt, Steven C Almo, Karen N Allen, Brian K Shoichet

Substrate deconstruction and the nonadditivity of enzyme recognition

底物解构和酶识别的非加和性

Barelier, Sarah; Cummings, Jennifer A; Rauwerdink, Alissa M; Hitchcock, Daniel S; Farelli, Jeremiah D; Almo, Steven C; Raushel, Frank M; Allen, Karen N; Shoichet, Brian K

Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs.

马来布鲁氏丝虫海藻糖-6-磷酸磷酸酶的结构揭示了驱虫药的关键设计原则

Farelli Jeremiah D, Galvin Brendan D, Li Zhiru, Liu Chunliang, Aono Miyuki, Garland Megan, Hallett Olivia E, Causey Thomas B, Ali-Reynolds Alana, Saltzberg Daniel J, Carlow Clotilde K S, Dunaway-Mariano Debra, Allen Karen N