日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.

确定能够逆转具有朊病毒样结构域的 RNA 结合蛋白的有害相变的 RNA 寡核苷酸。

Guo Lin, Mann Jacob R, Mauna Jocelyn C, Copley Katie E, Wang Hejia, Rubien Jack D, Bergmann Cristian A, Carey Jenny L, Merjane Jessica, Ngo Marilyn, Xu Jiazhen, Odeh Hana M, Lin JiaBei, Lee Bo Lim, Ganser Laura, Robinson Emma, Kim Kevin M, Murthy Anastasia C, Paul Tapas, Portz Bede, Gleixner Amanda M, Diaz Zamia, Smirnov Ashleigh, Padilla George, Lavorando Ellen, Espy Carolann, Shang Yulei, Huang Eric J, Chesi Alessandra, Fawzi Nicolas L, Myong Sua, Donnelly Christopher J, Shorter James

The glycine-arginine-rich motif of 53BP1 modulates RNA interactions necessary for its liquid-liquid phase separation during DNA Damage Response

53BP1 中富含甘氨酸-精氨酸的基序调节 RNA 相互作用,这对于其在 DNA 损伤反应过程中发生液-液相分离至关重要。

Terraneo, Federica; Ceccon, Marta; Sapkota, Oscar; Zheng, Tongyin; Brizioli, Matteo; Dello Stritto, Angela; Cummings, Samara; Codispoti, Simone; Ossolengo, Giuseppe; Orsenigo, Fabrizio; Magni, Serena; Gottinger, Andrea; Mattevi, Andrea; Fuxreiter, Monika; Fawzi, Nicolas L; Lottersberger, Francisca; Giavazzi, Fabio; d'Adda di Fagagna, Fabrizio

Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity.

破坏 FUS 朊病毒样结构域中的 β 折叠可以保持相分离和功能,但可以防止聚集和毒性。

Wake Noah, Alcalde Juan, Jutzi Daniel, Bajaj Anjali, Kour Sukhleen, Barai Mayur, Weng Shuo-Lin, Cummings Samara, Zheng Tongyin, Anderson Eric N, Wang Szu-Huan, Puterbaugh Ryan, Bosco Daryl A, Schuster Benjamin S, Mittal Jeetain, Pandey Udai Bhan, Ruepp Marc-David, Fawzi Nicolas L

Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain

TDP-43 C端结构域保守区螺旋介导多聚化的结构细节

Rizuan, Azamat; Shenoy, Jayakrishna; Mohanty, Priyesh; Dos Passos, Patricia M; Mercado Ortiz, José F; Bai, Leanna; Viswanathan, Renjith; Zaborowksy, Julia; Wang, Szu-Huan; Johnson, Victoria; Mamede, Lohany D; Titus, Amanda R; Ayala, Yuna M; Ghirlando, Rodolfo; Mittal, Jeetain; Fawzi, Nicolas L

Current practices in the study of biomolecular condensates: a community comment

生物分子凝聚体研究的现状:一位学者的评论

Alberti, Simon; Arosio, Paolo; Best, Robert B; Boeynaems, Steven; Cai, Danfeng; Collepardo-Guevara, Rosana; Dignon, Gregory L; Dimova, Rumiana; Elbaum-Garfinkle, Shana; Fawzi, Nicolas L; Fuxreiter, Monika; Gladfelter, Amy S; Honigmann, Alf; Jain, Ankur; Joseph, Jerelle A; Knowles, Tuomas P J; Lasker, Keren; Lemke, Edward A; Lindorff-Larsen, Kresten; Lipowsky, Reinhard; Mittal, Jeetain; Mukhopadhyay, Samrat; Myong, Sua; Pappu, Rohit V; Rippe, Karsten; Shelkovnikova, Tatyana A; Vecchiarelli, Anthony G; Wegmann, Susanne; Zhang, Huaiying; Zhang, Mingjie; Zubieta, Chloe; Zweckstetter, Markus; Dormann, Dorothee; Mittag, Tanja

Expanding the molecular grammar of polar residues and arginine in FUS phase separation

扩展FUS相分离中极性残基和精氨酸的分子语法

Wake, Noah; Weng, Shuo-Lin; Zheng, Tongyin; Wang, Szu-Huan; Kirilenko, Valentin; Mittal, Jeetain; Fawzi, Nicolas L

Small-molecule dissolution of stress granules by redox modulation benefits ALS models.

通过氧化还原调节溶解应激颗粒的小分子对 ALS 模型有益。

Uechi Hiroyuki, Sridharan Sindhuja, Nijssen Jik, Bilstein Jessica, Iglesias-Artola Juan M, Kishigami Satoshi, Casablancas-Antras Virginia, Poser Ina, Martinez Eduardo J, Boczek Edgar, Wagner Michael, Tomschke Nadine, de Jesus Domingues António M, Pal Arun, Doeleman Thom, Kour Sukhleen, Anderson Eric Nathaniel, Stein Frank, Lee Hyun O, Zhang Xiaojie, Fritsch Anatol W, Jahnel Marcus, Fürsch Julius, Murthy Anastasia C, Alberti Simon, Bickle Marc, Fawzi Nicolas L, Nadler André, David Della C, Pandey Udai B, Hermann Andreas, Stengel Florian, Davis Benjamin G, Baldwin Andrew J, Savitski Mikhail M, Hyman Anthony A, Wheeler Richard J

Solid trouble: tau and TDP-43 interaction in aggregation and pathology

固体麻烦:tau 和 TDP-43 在聚集和病理学中的相互作用

Fawzi, Nicolas L

Molecular insights into the effect of 1,6-hexanediol on FUS phase separation.

1,6-己二醇对FUS相分离影响的分子机制研究

Zheng Tongyin, Wake Noah, Weng Shuo-Lin, Perdikari Theodora Myrto, Murthy Anastasia C, Mittal Jeetain, Fawzi Nicolas L

Site-specific methionine oxidation alters structure and phase separation of TDP-43 C-terminal domain

位点特异性甲硫氨酸氧化会改变TDP-43 C端结构域的结构和相分离。

Ozguney, Busra; Puterbaugh, Ryan Z; Viswanathan, Renjith; Shenoy, Jayakrishna; Mohanty, Priyesh; Mittal, Jeetain; Fawzi, Nicolas L