日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Duchenne Muscular Dystrophy in Two Half-Brothers Due to Inherited 306 Kb Inverted Insertion of 10p15.1 into Intron 44 of the Dp427m Transcript of the DMD Gene

两个同父异母兄弟因遗传 306 Kb 的 10p15.1 反向插入到 DMD 基因 Dp427m 转录本的内含子 44 而患上杜氏肌营养不良症

Wayne M Jepsen, Andrew Fazenbaker, Keri Ramsey, Anna Bonfitto, Marcus Naymik, Bryce Turner, Jennifer Sloan, Nishant Tiwari, Saunder M Bernes, Derek E Neilson, Meredith Sanchez-Castillo, Matt J Huentelman, Vinodh Narayanan

Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer

AZD0754(一种经dnTGFβRII修饰、靶向STEAP2的CAR-T细胞疗法)在前列腺癌中的抗肿瘤活性

Peter Zanvit ,Dewald van Dyk ,Christine Fazenbaker ,Kelly McGlinchey ,Weichuan Luo ,Jessica M Pezold ,John Meekin ,Chien-Ying Chang ,Rosa A Carrasco ,Shannon Breen ,Crystal Sao-Fong Cheung ,Ariel Endlich-Frazier ,Benjamin Clark ,Nina J Chu ,Alessio Vantellini ,Philip L Martin ,Clare E Hoover ,Kenesha Riley ,Steve M Sweet ,David Chain ,Yeoun Jin Kim ,Eric Tu ,Nathalie Harder ,Sandrina Phipps ,Melissa Damschroder ,Ryan N Gilbreth ,Mark Cobbold ,Gordon Moody ,Emily E Bosco

ATP6V0C variants impair V-ATPase function causing a neurodevelopmental disorder often associated with epilepsy

ATP6V0C 变异会损害 V-ATPase 功能,导致神经发育障碍,这种障碍通常与癫痫有关。

Mattison, Kari A; Tossing, Gilles; Mulroe, Fred; Simmons, Callum; Butler, Kameryn M; Schreiber, Alison; Alsadah, Adnan; Neilson, Derek E; Naess, Karin; Wedell, Anna; Wredenberg, Anna; Sorlin, Arthur; McCann, Emma; Burghel, George J; Menendez, Beatriz; Hoganson, George E; Botto, Lorenzo D; Filloux, Francis M; Aledo-Serrano, Ángel; Gil-Nagel, Antonio; Tatton-Brown, Katrina; Verbeek, Nienke E; van der Zwaag, Bert; Aleck, Kyrieckos A; Fazenbaker, Andrew C; Balciuniene, Jorune; Dubbs, Holly A; Marsh, Eric D; Garber, Kathryn; Ek, Jakob; Duno, Morten; Hoei-Hansen, Christina E; Deardorff, Matthew A; Raca, Gordana; Quindipan, Catherine; van Hirtum-Das, Michele; Breckpot, Jeroen; Hammer, Trine Bjørg; Møller, Rikke S; Whitney, Andrea; Douglas, Andrew G L; Kharbanda, Mira; Brunetti-Pierri, Nicola; Morleo, Manuela; Nigro, Vincenzo; May, Halie J; Tao, James X; Argilli, Emanuela; Sherr, Elliot H; Dobyns, William B; Baines, Richard A; Warwicker, Jim; Parker, J Alex; Banka, Siddharth; Campeau, Philippe M; Escayg, Andrew

Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer

使用工程抗体和双马来酰亚胺吡咯并苯二氮卓二聚体制备的药物抗体比为 1 的均质抗体-药物偶联物的设计和表征

Jason B White, Ryan Fleming, Luke Masterson, Ben T Ruddle, Haihong Zhong, Christine Fazenbaker, Patrick Strout, Kim Rosenthal, Molly Reed, Vanessa Muniz-Medina, Philip Howard, Rakesh Dixit, Herren Wu, Mary Jane Hinrichs, Changshou Gao, Nazzareno Dimasi

Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition

使用抗体连接的吡咯并苯二氮卓二聚体(联合或不联合 PARP 抑制)改善 BRCA 突变肿瘤的治疗窗口

Haihong Zhong, Cui Chen, Ravinder Tammali, Shannon Breen, Jing Zhang, Christine Fazenbaker, Maureen Kennedy, James Conway, Brandon W Higgs, Nicholas Holoweckyj, Rajiv Raja, Jay Harper, Andrew J Pierce, Ronald Herbst, David A Tice

Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties

将 scFv 插入全长 IgG1 单克隆抗体的铰链结构域,可形成具有稳健特性的四价双特异性分子

Binyam Bezabeh, Ryan Fleming, Christine Fazenbaker, Haihong Zhong, Karen Coffman, Xiang-Qing Yu, Ching Ching Leow, Nerea Gibson, Susan Wilson, C Kendall Stover, Herren Wu, Changshou Gao, Nazzareno Dimasi

Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody

双特异性抗体介导的靶向 Fcγ 受体 (FcγR) 清除

Srinath Kasturirangan, G Jonah Rainey, Linda Xu, Xinwei Wang, Alyse Portnoff, Tracy Chen, Christine Fazenbaker, Helen Zhong, Jared Bee, Zhutian Zeng, Craig Jenne, Herren Wu, Changshou Gao

Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors

抗体依赖性细胞介导的细胞毒效应增强的 EphA2 激动剂单克隆抗体表现出对人类肿瘤的强效活性

Elizabeth M Bruckheimer, Christine A Fazenbaker, Sandra Gallagher, Kathy Mulgrew, Stacy Fuhrmann, Karen T Coffman, William Walsh, Shannon Ready, Kim Cook, Melissa Damschroder, Michael Kinch, Peter A Kiener, Rob Woods, Changshou Gao, William Dall'Acqua, Herren Wu, Steven Coats

A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo

针对 EphA2 的人类抗体-药物偶联物可抑制体内肿瘤生长

Dowdy Jackson, John Gooya, Shenlan Mao, Krista Kinneer, Linda Xu, Margarita Camara, Christine Fazenbaker, Ryan Fleming, Sudha Swamynathan, Damon Meyer, Peter D Senter, Changshou Gao, Herren Wu, Michael Kinch, Steven Coats, Peter A Kiener, David A Tice