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Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer

通过卵巢癌中的功能性 CRISPR-Cas9 筛选确定了 PARP 抑制剂和卡铂反应的重叠基因依赖性

Ricardo Coelho #, Alessandra Tozzi #, Muriel Disler #, Flavio Lombardo, André Fedier, Mónica Núñez López, Florian Freuler, Francis Jacob, Viola Heinzelmann-Schwarz

肿瘤

卵巢癌

发表日期：2022

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MyCTC chip: microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies

MyCTC芯片：基于微流控技术的药物筛选，利用来自液体活检的患者来源肿瘤细胞

期刊:Microsystems & Nanoengineering

影响因子:7.3

doi:10.1038/s41378-022-00467-y

Fabienne D Schwab # ，Manuel C Scheidmann # ，Lauren L Ozimski # ，André Kling # ，Lucas Armbrecht ，Till Ryser ，Ilona Krol ，Karin Strittmatter ，Bich Doan Nguyen-Sträuli ，Francis Jacob ，André Fedier ，Viola Heinzelmann-Schwarz ，Andreas Wicki ，Petra S Dittrich ，Nicola Aceto

Exposure to escalating olaparib does not induce acquired resistance to PARPi and to other chemotherapeutic compounds in ovarian cancer cell lines

暴露于升级的奥拉帕尼不会在卵巢癌细胞系中诱导对 PARPi 和其他化疗化合物的获得性耐药性

期刊:International Journal of Oncology

影响因子:4.5

doi:10.3892/ijo.2022.5379

André Fedier, Nadia Maggi, Alessandra Tozzi, Muriel Disler, Ricardo Coelho, Francis Jacob, Viola Heinzelmann-Schwarz

Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

富含胶原蛋白的大网膜是整合素α2介导的腹膜转移的转移前微环境。

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.59442

Yen-Lin Huang ，Ching-Yeu Liang ，Danilo Ritz ，Ricardo Coelho ，Dedy Septiadi ，Manuela Estermann ，Cécile Cumin ，Natalie Rimmer ，Andreas Schötzau ，Mónica Núñez López ，André Fedier ，Martina Konantz ，Tatjana Vlajnic ，Diego Calabrese ，Claudia Lengerke ，Leonor David ，Barbara Rothen-Rutishauser ，Francis Jacob ，Viola Heinzelmann-Schwarz

发表日期：2020

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Outcome in serous ovarian cancer is not associated with LATS expression

浆液性卵巢癌的结果与 LATS 表达无关

期刊:Journal of Cancer Research and Clinical Oncology

影响因子:2.7

doi:10.1007/s00432-019-03037-4

Céline Montavon, Gregor R Stricker, Andreas Schoetzau, Viola Heinzelmann-Schwarz, Francis Jacob, André Fedier

ABO blood groups as a prognostic factor for recurrence in ovarian and vulvar cancer

ABO血型作为卵巢癌和外阴癌复发的预后因素

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0195213

Montavon Sartorius, Céline; Schoetzau, Andreas; Kettelhack, Henriette; Fink, Daniel; Hacker, Neville F; Fedier, André; Jacob, Francis; Heinzelmann-Schwarz, Viola

Diaphragmatic smears are not of additional benefit in the detection of peritoneal spread in gynecological cancers

膈肌涂片对检测妇科癌症腹膜转移没有额外益处。

期刊:Experimental and Therapeutic Medicine

影响因子:2.3

doi:10.3892/etm.2018.5957

Montavon, Celine; Mirza, Uzma; Fedier, Andre; Schoetzau, Andreas; Zanetti Dällenbach, Rosanna; Heinzelmann-Schwarz, Viola

MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells

卵巢癌中的 MELK 表达与不良预后相关，OTSSP167 抑制 MELK 可消除卵巢癌细胞的增殖和活力

期刊:Gynecologic Oncology

影响因子:4.5

doi:10.1016/j.ygyno.2017.02.016

Reto S Kohler, Henriette Kettelhack, Alexandra M Knipprath-Mészaros, André Fedier, Andreas Schoetzau, Francis Jacob, Viola Heinzelmann-Schwarz

Blood Plasma-Derived Anti-Glycan Antibodies to Sialylated and Sulfated Glycans Identify Ovarian Cancer Patients

血浆中针对唾液酸化和硫酸化聚糖的抗聚糖抗体可用于识别卵巢癌患者

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0164230

Pochechueva, Tatiana; Chinarev, Alexander; Schoetzau, Andreas; Fedier, André; Bovin, Nicolai V; Hacker, Neville F; Jacob, Francis; Heinzelmann-Schwarz, Viola

Protocol for quantifying drug sensitivity in 3D patient-derived ovarian cancer models

用于量化 3D 患者来源卵巢癌模型药物敏感性的方案

Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer

通过卵巢癌中的功能性 CRISPR-Cas9 筛选确定了 PARP 抑制剂和卡铂反应的重叠基因依赖性

MyCTC chip: microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies

MyCTC芯片：基于微流控技术的药物筛选，利用来自液体活检的患者来源肿瘤细胞

Exposure to escalating olaparib does not induce acquired resistance to PARPi and to other chemotherapeutic compounds in ovarian cancer cell lines

暴露于升级的奥拉帕尼不会在卵巢癌细胞系中诱导对 PARPi 和其他化疗化合物的获得性耐药性

Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

富含胶原蛋白的大网膜是整合素α2介导的腹膜转移的转移前微环境。

Outcome in serous ovarian cancer is not associated with LATS expression

浆液性卵巢癌的结果与 LATS 表达无关

ABO blood groups as a prognostic factor for recurrence in ovarian and vulvar cancer

ABO血型作为卵巢癌和外阴癌复发的预后因素

Diaphragmatic smears are not of additional benefit in the detection of peritoneal spread in gynecological cancers

膈肌涂片对检测妇科癌症腹膜转移没有额外益处。

MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells

卵巢癌中的 MELK 表达与不良预后相关，OTSSP167 抑制 MELK 可消除卵巢癌细胞的增殖和活力

Blood Plasma-Derived Anti-Glycan Antibodies to Sialylated and Sulfated Glycans Identify Ovarian Cancer Patients

血浆中针对唾液酸化和硫酸化聚糖的抗聚糖抗体可用于识别卵巢癌患者