日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response

SARS-CoV-2 和 MERS-CoV 通过 nsp1 干扰宿主蛋白合成,对整合应激反应产生不同的影响。

Parenti, Nicholas A; Cusic, Renee; Renner, David M; Jackson, Nathaniel; Ye, Chengjin; Tan, Li Hui; Pfannenstiel, Jessica J; Fehr, Anthony R; Cohen, Noam A; Martinez-Sobrido, Luis; Burke, James M; Weiss, Susan R

An autoimmunity-associated allele of PTPN22 enhances innate antiviral immunity to protect against acute coronavirus infection

PTPN22 的一个与自身免疫相关的等位基因可增强先天性抗病毒免疫力,从而抵御急性冠状病毒感染。

Bevis, Alec M; Rosa, Kathryn J L H; Schwarting, Nancy; Cockerham, Tammy R; Kerr, Catherine M; More, Sunil; Fehr, Anthony R; Orozco, Robin C

Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication

鉴定出一系列基于吡咯并嘧啶的SARS-CoV-2 Mac1抑制剂,这些抑制剂能够抑制冠状病毒的复制

Pfannenstiel, Jessica J; Duong, Men Thi Hoai; Cluff, Daniel; Sherrill, Lavinia M; Colquhoun, Iain; Cadoux, Gabrielle; Thorne, Devyn; Pääkkönen, Johan; Schemmel, Nathaniel F; O'Connor, Joseph; Saenjamsai, Pradtahna; Feng, Mei; Parthasarathy, Srivatsan; Hageman, Michael J; Johnson, David K; Roy, Anuradha; Lehtiö, Lari; Ferraris, Dana V; Fehr, Anthony R

PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses

PARP14是一种干扰素诱导的宿主因子,它能促进干扰素的产生并影响多种病毒的复制。

Parthasarathy, Srivatsan; Saenjamsai, Pradtahna; Hao, Hongping; Ferkul, Anna; Pfannenstiel, Jessica J; Bejan, Daniel S; Chen, Yating; Suder, Ellen L; Schwarting, Nancy; Aikawa, Masanori; Muhlberger, Elke; Hume, Adam J; Orozco, Robin C; Sullivan, Christopher S; Cohen, Michael S; Davido, David J; Fehr, Anthony R

IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice

IFN-γ信号传导是鼠肝炎病毒(MHV)JHM株在感染小鼠脑内有效复制所必需的。

Kerr, Catherine M; Proctor-Roser, Macie A; Parthasarathy, Srivatsan; O'Connor, Joseph J; Pfannenstiel, Jessica J; Orozco, Robin C; Fehr, Anthony R

SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response

SARS-CoV-2 和 MERS-CoV 通过 nsp1 干扰宿主蛋白合成,对整合应激反应产生不同的影响。

Parenti, Nicholas A; Cusic, Renee; Renner, David M; Jackson, Nathaniel; Ye, Chengjin; Tan, Li Hui; Pfannenstiel, Jessica J; Fehr, Anthony R; Cohen, Noam A; Martinez-Sobrido, Luis; Burke, James M; Weiss, Susan R

An Autoimmunity-associated allele of PTPN22 enhances innate antiviral immunity to protect against acute coronavirus infection

PTPN22 的一个与自身免疫相关的等位基因可增强先天性抗病毒免疫力,从而抵御急性冠状病毒感染。

Bevis, Alec M; Rosa, Kathryn J L H; Schwarting, Nancy; Cockerham, Tammy R; Kerr, Catherine M; More, Sunil; Fehr, Anthony R; Orozco, Robin C

Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target.

发现靶向 SARS-CoV-2 Mac1 并抑制冠状病毒复制的 2-酰胺-3-甲基酯噻吩类化合物,验证 Mac1 作为抗病毒靶点

Wazir Sarah, Parviainen Tomi A O, Pfannenstiel Jessica J, Duong Men Thi Hoai, Cluff Daniel, Sowa Sven T, Galera-Prat Albert, Ferraris Dana, Maksimainen Mirko M, Fehr Anthony R, Heiskanen Juha P, Lehtiö Lari

Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication

多个β冠状病毒宏结构域2环中高度保守的异亮氨酸残基的突变表明,增强的ADP-核糖结合不利于病毒复制。

Kerr, Catherine M; Pfannenstiel, Jessica J; Alhammad, Yousef M; O'Connor, Joseph J; Ghimire, Roshan; Shrestha, Rakshya; Khattabi, Reem; Saenjamsai, Pradtahna; Parthasarathy, Srivatsan; McDonald, Peter R; Gao, Philip; Johnson, David K; More, Sunil; Roy, Anuradha; Channappanavar, Rudragouda; Fehr, Anthony R

Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication.

鉴定出一系列基于吡咯并嘧啶的SARS-CoV-2 Mac1抑制剂,这些抑制剂能够抑制冠状病毒的复制

Pfannenstiel Jessica J, Duong Men Thi Hoai, Cluff Daniel, Sherrill Lavania M, Colquhoun Iain, Cadoux Gabrielle, Thorne Devyn, Pääkkönen Johan, Schemmel Nathaniel F, O'Connor Joseph, Saenjamsai Pradtahna, Feng Mei, Hageman Michael J, Johnson David K, Roy Anuradha, Lehtiö Lari, Ferraris Dana V, Fehr Anthony R