日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics

KRAS4a 和 KRAS4b 对 RAS-RAF 膜动力学表现出不同的脂质依赖性调控作用

Georgouli, Konstantia; Tempkin, Jeremy O B; Stanton, Liam G; Oppelstrup, Tomas; Shrestha, Rebika; Carpenter, Timothy S; Aydin, Fikret; Zhang, Xiaohua; Bhatia, Harsh; Yang, Yue; Van, Que N; Bonilla, Pedro Andrade; Gulten, Gulcin; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moon, Joseph Y; Dharuman, Gautham; Hengartner, Nicolas W; Simanshu, Dhirendra K; Tran, Timothy H; Nguyen, Kien; Stanley, Christopher B; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Glosli, James N; Gnanakaran, Sandrasegaram; Turbyville, Thomas J; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations

通过多尺度模拟揭示RAS-RAF复合物的动力学和脂质膜耦合

Carpenter, Timothy S; Aydin, Fikret; Neale, Chris; Van, Que N; Zhang, Xiaohua; Bhatia, Harsh; Sidabras, Jason W; Frank, Peter H; Georgouli, Konstantia; Tempkin, Jeremy O B; Casamayor, Violeta Burns; Gulten, Gulcin; Shrestha, Rebika; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moody, Adam; Moon, Joseph Y; Oppelstrup, Tomas; Glosli, James N; Dharuman, Gautham; Wong, Sergio; Liu, Shusen; Hengartner, Nicolas W; López, Cesar A; Nguyen, Kien; Stanley, Christopher B; Stanton, Liam G; Patel, Lara; Reddy, Tyler; Turbyville, Thomas J; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Gnanakaran, Sandrasegaram; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.

发现 BBO-8520,一种首创的直接共价双重抑制剂,可抑制 GTP 结合 (ON) 和 GDP 结合 (OFF) 的 KRASG12C

Maciag Anna E, Stice James P, Wang Bin, Sharma Alok K, Chan Albert H, Lin Ken, Singh Devansh, Dyba Marcin, Yang Yue, Setoodeh Saman, Smith Brian P, Ju Jin Hyun, Jeknic Stevan, Rabara Dana, Zhang Zuhui, Larsen Erik K, Esposito Dominic, Denson John-Paul, Ranieri Michela, Meynardie Mary, Mehdizadeh Sadaf, Alexander Patrick A, Abreu Blanco Maria, Turner David M, Xu Rui, Lightstone Felice C, Wong Kwok-Kin, Stephen Andrew G, Wang Keshi, Simanshu Dhirendra K, Sinkevicius Kerstin W, Nissley Dwight V, Wallace Eli, McCormick Frank, Beltran Pedro J

An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state

体外BRAF激活实验阐明了驱动BRAF自身抑制状态解体的分子机制

Ritt, Daniel A; Durrant, David E; Drew, Matthew R; Sandin, Suzanne I; Martinez Fiesco, Juliana A; Zhang, Xiaohua; Aydin, Fikret; Carpenter, Timothy S; Scheidemantle, Grace M; D'Ippolito, Robert A; Sohn, Alexandria L; DeHart, Caroline J; Shrestha, Rebika; Snead, Kelly; Hull, Jenna; Tempkin, Jeremy O B; Yang, Yue; Lightstone, Felice C; Streitz, Frederick H; Zhang, Ping; Turbyville, Thomas J; Stephen, Andrew G; Esposito, Dominic; Ingólfsson, Helgi I; Nissley, Dwight V; Morrison, Deborah K

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

通过对 CaaX 盒半胱氨酸进行直接共价攻击,阻断 KRAS4b 的 C 端加工

Maciag Anna E, Yang Yue, Sharma Alok K, Turner David M, DeHart Caroline J, Abdelkarim Hazem, Fan Lixin, Smith Brian P, Kumari Vandana, Dyba Marcin, Rigby Megan, Castillo Badillo Jean A, Adams Lauren, Fornelli Luca, Fox Stephen, Brafman Alla, Turbyville Thomas, Gillette William, Messing Simon, Agamasu Constance, Wolfe Andrew L, Gysin Stephan, Chan Albert H, Simanshu Dhirendra K, Esposito Dominic, Chertov Oleg, Stephen Andrew G, Arkin Michelle, Renslo Adam, Kelleher Neil L, Gaponenko Vadim, Lightstone Felice C, Nissley Dwight V, McCormick Frank

Integrating Ultra-Coarse-Grained Protein Models into Accessible Workflows for Multiscale Molecular Dynamics

将超粗粒化蛋白质模型集成到易于使用的多尺度分子动力学工作流程中

Chi, Bryce Tu; Fulcar, Stephanie; Ipe, Jonathan; Schleifer, Olivia; Subramanian, Rohan; Vlases, Claire; Matasci, Naim; Georgouli, Konstantia; Pottier, Loïc; Hsu, Tim; Carpenter, Timothy S; Nissley, Dwight V; Lightstone, Felice C; Streitz, Frederick H; Ingólfsson, Helgi I; Aydin, Fikret

Enhanced Exploration of Protein Conformational Space through Integration of Ultra-Coarse-Grained Models to Multiscale Workflows

通过将超粗粒化模型集成到多尺度工作流程中,增强对蛋白质构象空间的探索

Aydin, Fikret; Georgouli, Konstantia; Pottier, Loïc; Oppelstrup, Tomas; Carpenter, Timothy S; Tempkin, Jeremy O B; Bremer, Peer-Timo; Nissley, Dwight V; Streitz, Frederick H; Lightstone, Felice C; Ingólfsson, Helgi I

Remdesivir Use in Pediatric Patients with Acute SARS-CoV-2 Infection Is Safe and Well Tolerated

瑞德西韦用于治疗急性SARS-CoV-2感染的儿科患者安全且耐受性良好

Nieves, Delma J; Tran, M Tuan; Singh, Jasjit; Ashouri, Negar; Morphew, Tricia; Lusk, Jennifer G; Adler-Shohet, Felice C; Marano, Rachel; Osborne, Stephanie; Strickland, Jennifer; Arrieta, Antonio C

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State

体外BRAF激活实验阐明了驱动自身抑制状态BRAF解体的分子机制

Ritt, Daniel A; Durrant, David E; Drew, Matthew R; Sandin, Suzanne I; Fiesco, Juliana A Martinez; Zhang, Xiaohua; Aydin, Fikret; Carpenter, Timothy S; Scheidemantle, Grace M; D'Ippolito, Robert A; Sohn, Alexandria L; DeHart, Caroline J; Shrestha, Rebika; Snead, Kelly; Hull, Jenna; Tempkin, Jeremy O B; Yang, Yue; Lightstone, Felice C; Streitz, Frederick H; Zhang, Ping; Turbyville, Thomas J; Stephen, Andrew G; Esposito, Dominic; Ingolfsson, Helgi I; Nissley, Dwight V; Morrison, Deborah K

Free energy and flexibility analysis of autoinhibited human BRAF

对自身抑制的人类BRAF进行自由能和柔性分析

Tempkin, Jeremy O B; Aydin, Fikret; Essiz, Sebnem; Yang, Yue; Carpenter, Timothy S; Durrant, David E; Morrison, Deborah K; Ingólfsson, Helgi I; Streitz, Frederick H; Nissely, Dwight V; Lightstone, Felice C; Zhang, Xiaohua