日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.

对影响完全化学修饰的siRNA功效的siRNA和mRNA特征进行系统分析

Davis Sarah M, Hildebrand Samuel, MacMillan Hannah J, Monopoli Kathryn R, Buchwald Julianna, Sousa Jacquelyn, Cooper David, Ly Socheata, Echeverria Dimas, McHugh Nicholas, Ferguson Chantal, Coles Andrew, Hariharan Vignesh N, O'Reilly Daniel, Tang Qi, Furgal Raymond, Yamada Ken, Alterman Julia F, Gilbert James W, Knox Emily, Pineda Yamilett, Weston Caitlyn N, Baer Christina E, Pai Athma A, Khvorova Anastasia

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

RNAi介导的SOD1基因沉默显著延长了ALS小鼠的生存期并改善了其功能预后。

Weiss, Alexandra; Gilbert, James W; Rivera Flores, Iris Valeria; Belgrad, Jillian; Ferguson, Chantal; Dogan, Elif O; Wightman, Nicholas; Mocarski, Kit; Echeverria, Dimas; Harkins, Ashley L; Summers, Ashley; Bramato, Brianna; McHugh, Nicholas; Furgal, Raymond; Yamada, Nozomi; Cooper, David; Monopoli, Kathryn; Godinho, Bruno M D C; Hassler, Matthew R; Yamada, Ken; Greer, Paul; Henninger, Nils; Brown, Robert H Jr; Khvorova, Anastasia

Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model

单次注射靶向 MECP2 的治疗性二价 siRNA 可使 MECP2 重复小鼠模型免于死亡一年。

Hariharan, Vignesh N; Summers, Ashley; Clipperton-Allen, Amy E; Caiazzi, Jillian; Hildebrand, Samuel R; O'Reilly, Daniel; Tang, Qi; Kennedy, Zachary; Echeverria, Dimas; McHugh, Nicholas; Cooper, David; Souza, Jacqueline; Ferguson, Chantal; Bogdanik, Laurent; Coenraads, Monica; Khvorova, Anastasia

Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.

量化 ASO 和 siRNA 缀合物在胶质母细胞瘤异种移植瘤体内的活性谱

Sarli Samantha L, Fakih Hassan H, Kelly Karen, Devi Gitali, Rembetsy-Brown Julia M, McEachern Holly R, Ferguson Chantal M, Echeverria Dimas, Lee Jonathan, Sousa Jacquelyn, Sleiman Hanadi F, Khvorova Anastasia, Watts Jonathan K

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease

二价siRNA介导的MSH3沉默可阻断亨廷顿病小鼠模型中的体细胞重复序列扩增

O'Reilly, Daniel; Belgrad, Jillian; Ferguson, Chantal; Summers, Ashley; Sapp, Ellen; McHugh, Cassandra; Mathews, Ella; Boudi, Adel; Buchwald, Julianna; Ly, Socheata; Moreno, Dimas; Furgal, Raymond; Luu, Eric; Kennedy, Zachary; Hariharan, Vignesh; Monopoli, Kathryn; Yang, X William; Carroll, Jeffery; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

突变型亨廷顿蛋白信使RNA在啮齿动物和人类大脑中形成神经元核簇

Ly, Socheata; Didiot, Marie-Cécile; Ferguson, Chantal M; Coles, Andrew H; Miller, Rachael; Chase, Kathryn; Echeverria, Dimas; Wang, Feng; Sadri-Vakili, Ghazaleh; Aronin, Neil; Khvorova, Anastasia

Interventional oncology update

介入肿瘤学最新进展

Newbury, Alex; Ferguson, Chantal; Valero, Daniel Alvarez; Kutcher-Diaz, Roberto; McIntosh, Lacey; Karamanian, Ara; Harman, Aaron

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

利用治疗性siRNA进行的给药途径比较研究表明,多塞特绵羊体内存在广泛的基因调控。

Ferguson, Chantal M; Godinho, Bruno Mdc; Alterman, Julia F; Coles, Andrew H; Hassler, Matthew; Echeverria, Dimas; Gilbert, James W; Knox, Emily G; Caiazzi, Jillian; Haraszti, Reka A; King, Robert M; Taghian, Toloo; Puri, Ajit; Moser, Richard P; Gounis, Matthew J; Aronin, Neil; Gray-Edwards, Heather; Khvorova, Anastasia

Impact of Ipsilateral Blood Draws, Injections, Blood Pressure Measurements, and Air Travel on the Risk of Lymphedema for Patients Treated for Breast Cancer

同侧抽血、注射、血压测量和航空旅行对乳腺癌患者淋巴水肿风险的影响

Ferguson, Chantal M; Swaroop, Meyha N; Horick, Nora; Skolny, Melissa N; Miller, Cynthia L; Jammallo, Lauren S; Brunelle, Cheryl; O'Toole, Jean A; Salama, Laura; Specht, Michelle C; Taghian, Alphonse G

Immediate Implant Reconstruction Is Associated With a Reduced Risk of Lymphedema Compared to Mastectomy Alone: A Prospective Cohort Study

与单纯乳房切除术相比,即刻植入物重建可降低淋巴水肿的风险:一项前瞻性队列研究

Miller, Cynthia L; Colwell, Amy S; Horick, Nora; Skolny, Melissa N; Jammallo, Lauren S; O'Toole, Jean A; Shenouda, Mina N; Sadek, Betro T; Swaroop, Meyha N; Ferguson, Chantal M; Smith, Barbara L; Specht, Michelle C; Taghian, Alphonse G